Yuji Heike

Faculty & Position:Public Health  professor
Last Updated: Sep. 09, 2019 at 11:47

Researcher Profile & Settings


  • PhD


  • 博士(医学)(PhD)

Research Activities

Research Areas

  • Basic medicine / Immunology
  • Society medicine / Epidemiology and preventive medicine
  • Society medicine / Hygiene and public health
  • Oncology / Tumor therapeutics


  • Monitoring of Tumor-specific T lymphocyte after allogneic hematopoietic stem cell transplantation
    HEIKE Yuji, HOSHI Yuriko, TAKAUE Yoichi, NOMURA Kazuhiro
    Cytometry research = 日本サイトメトリー学会機関誌 17(2) 31-37 Sep. 2007
  • Reduced Internsity Stem Cell Transplantation against Hematologic and Solid Malignancies
    Makiyama Hiroaki, Heike Yuji
    Japanese journal of apheresis 26(2) 238-244 May 2007
    The reduced intensity conditioning (RIC) regimen was developed for decreasing pretreatment relative toxicity by massive chemotherapy and irradiation. It enables elderly patients and those who have organ dysfunction to receive hematopoietic stem cell transplantation. As a result of reducing these toxicities, we were able to evaluate treatment relative toxicities of hematopoietic stem cell transplantation (HSCT) by NCI-CTC and its treatment was even expanded to include solid tumors and severe autoimmune diseases. In this paper, we summarize the history, concepts, and recent examined studies containing our experiments with RIC regimen against chemotherapy-resistant hematopoietic malignancies and solid tumors.
  • Immunoreconstitution of reduced intensity stem cell transplantation
    Journal of germfree life and gnotobiology 33(1) 44-47 Jun. 2003
    HEIKE Yuji
    Japanese Journal of National Medical Services 57(6) 409-413 2003
    cBRCA-1 and BRCA-2 are gene mutations that cause familial breast cancer. Clinical applications of genetic testing have been started mainly in the U.S. Although several methods of genetic testing are used, the whole sequence strategy is currently the most trustworthy method However, this method is expensive, labor intensive, and difficult to perform. Therefore, many groups studied screening methods, including SSCP, TGGE, DGGE, PTT, and DHPLC, to determine the best method for easily finding gene mutations. Compared with the other screening methods, DHPLC had the highest mutation detection rate. In Japan, the opportunity to genetically diagnose familial breast cancer is gradually rising with the increased number of breast cancer patients. However, the relationship between gene mutations and penetration is currently unclear in Japanese patients. Future studies are needed to collect this fundamental information as quickly as possible.

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