Masaki Shinoda

Faculty & Position:Neurosurgery Department  doctor
Last Updated: May 22, 2019 at 05:03

Researcher Profile & Settings

Academic & Professional Experience

  • Oct. 2012Mar. 2014Chairman, St. Luke's International Hospital
  • Dec. 2005Sep. 2012Director, St. Luke's International Hospital
  • Apr. 2002Nov. 2005Associate Professor, Tokai University
  • Apr. 1998Mar. 2002Assistant Professor, Toque University


  • 医学博士

Research Activities

Research Areas

  • Clinical surgery / Neurosurgery

Research Interests

    , trkC , trkB , trkA , BDNF , hydrocephalus , MHC class I , microglia , neurotrophin , NT-3 , NGF , MHC class II , Cine MRI , Neuro-Endoscopic Surgery , NPH , LOVA , cardiac-gated cine-MRI

Published Papers

  • A case of radiation induced papillary meningioma appeared after 31 years from the initial treatment
    Masaki Shinoda
    Nervous System in Children 41(2) 233-237 Mar. 2016 [Refereed]
  • Basilar dolichoectasia and the spontaneous intradural vertebral artery dissection.
    Matsukawa H, Shinoda M, Fujii M, Uemura A, Takahashi O, Niimi Y.
    Brain Injury 30(1) 90-94 Jan. 2016 [Refereed]
  • Foramen spinosum and middle meningeal artery in moyamoya disease: Preliminary results of a pilot study.
    Matsukawa H, Fujii M, Murakata A, Shinoda M, Takahashi O
    Brain injury 1-6 Jun. 2015 [Refereed]
  • Arterial stiffness as a risk factor for cerebral aneurysm.
    Matsukawa H, Shinoda M, Fujii M, Uemura A, Takahashi O, Niimi Y.
    Acta Neurol Scand 130(6) 394-399 Dec. 2014 [Refereed]
  • Basilar extension and posterior inferior cerebellar artery involvement as risk factors for progression of the unruptured spontaneous intradural vertebral artery dissection.
    Matsukawa H, Shinoda M, Fujii M, Takahashi O, Uemura A, Niimi Y
    Journal of neurology, neurosurgery, and psychiatry 85(9) 1049-1054 Sep. 2014 [Refereed]
  • Morphological and clinical risk factors for posterior communicating artery aneurysm rupture.
    Matsukawa H, Fujii M, Akaike G, Uemura A, Takahashi O, Niimi Y, Shinoda M
    Journal of neurosurgery 120(1) 104-110 Jan. 2014 [Refereed]
  • Impact of body mass index on the location of spontaneous intracerebral hemorrhage.
    Matsukawa H, Shinoda M, Fujii M, Takahashi O, Yamamoto D, Murakata A, Ishikawa R
    World neurosurgery 79(3-4) 478-483 Mar. 2013 [Refereed]
  • Acute alcohol intoxication, diffuse axonal injury and intraventricular bleeding in patients with isolated blunt traumatic brain injury.
    Matsukawa H, Shinoda M, Fujii M, Takahashi O, Murakata A, Yamamoto D
    Brain injury 27(12) 1409-1414 2013 [Refereed]
  • Intraventricular hemorrhage on computed tomography and corpus callosum injury on magnetic resonance imaging in patients with isolated blunt traumatic brain injury.
    Matsukawa H, Shinoda M, Fujii M, Takahashi O, Murakata A, Yamamoto D, Sumiyoshi S, Ishikawa R
    Journal of neurosurgery 117(2) 334-339 Aug. 2012 [Refereed]
  • Relationships among hematoma diameter, location categorized by vascular territory, and 1-year outcome in patients with cerebellar hemorrhage.
    Matsukawa H, Shinoda M, Fujii M, Takahashi O, Yamamoto D, Murakata A, Ishikawa R
    World neurosurgery 77(3-4) 507-511 Mar. 2012 [Refereed]
  • Differences in vertebrobasilar artery morphology between spontaneous intradural vertebral artery dissections with and without subarachnoid hemorrhage.
    Matsukawa H, Shinoda M, Fujii M, Takahashi O, Murakata A, Ishikawa R
    Cerebrovascular diseases (Basel, Switzerland) 34(5-6) 393-399 2012 [Refereed]
  • Genu of corpus callosum as a prognostic factor in diffuse axonal injury.
    Matsukawa H, Shinoda M, Fujii M, Takahashi O, Yamamoto D, Murakata A, Ishikawa R
    Journal of neurosurgery 115(5) 1019-1024 Nov. 2011 [Refereed]
  • Guideline for management and treatment of fetal and congenital hydrocephalus: Center Of Excellence-Fetal and Congenital Hydrocephalus Top 10 Japan Guideline 2011.
    Oi S, Inagaki T, Shinoda M, Takahashi S, Ono S, Date I, Nomura S, Miwa T, Araki T, Ito S, Uchikado H, Takemoto O, Shirane R, Nishimoto H, Tashiro Y, Matsumura A, COE-Fetal and Congenital Hydrocephalus Top 10 Japan Study Group
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 27(10) 1563-1570 Oct. 2011 [Refereed]
  • Genu of corpus callosum in diffuse axonal injury induces a worse 1-year outcome in patients with traumatic brain injury.
    Matsukawa H, Shinoda M, Fujii M, Takahashi O, Yamamoto D, Murakata A, Ishikawa R
    Acta neurochirurgica 153(8) 1687-93; discussion 1693 Aug. 2011 [Refereed]
  • Antiplatelet agents are risk factors for cerebellar hemorrhage in patients with primary intracerebral hemorrhage.
    Matsukawa H, Shinoda M, Yamamoto D, Fujii M, Murakata A, Ishikawa R, Omata F
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20(4) 346-351 Jul. 2011 [Refereed]
  • Comparison of clinical characteristics and MR angiography appearance in patients with spontaneous intradural vertebral artery dissection with or without subarachnoid hemorrhage.
    Matsukawa H, Fujii M, Shinoda M, Takahashi O, Yamamoto D, Murakata A, Ishikawa R
    Journal of neurosurgery 115(1) 108-112 Jul. 2011 [Refereed]
  • Neuroendoscopic basket dilation technique for the fenestration of the ventricular wall or intracranial cysts--technical note.
    Matsumae M, Atsumi H, Shinoda M, Yamamoto M, Ikeya Y, Takeuchi M, Takamiya Y, Honda Y, Mamata Y, Oda S
    Neurol Med Chir 44(6) 331-334 Jun. 2004 [Refereed]
  • NGF, NT-3 and Trk C mRNAs are Upregulated, But Not Trk mRNA in the periventricular structures in Experimental Hydrocephalus
    Shinoda M, Hidaka M, Lindqvist E, Söderström S, Matsumae M, Oi S, Tsugane R, Ebendal T, Olson L
    Child’s Nervous System 17 704-712 2001 [Refereed]
  • Minor immunoreactivity in GDNF-, BDNF, or NT-3-treated substantia nigra allografts.
    Shinoda M, Hoffer BJ, Olson L
    J Neural Transplant Plast 6(2) 83-96 Jun. 1997 [Refereed]
  • Microglial cell responses to fetal ventral mesencephalic tissue grafting and to active and adoptive immunizations.
    Masaki Shinoda, John L. Hudson, Ingrid Strömberg, Barry J. Hoffer, John W. Moorhead, Lars Olson
    Exp Neurol 141(2) 173-180 1997 [Refereed]
  • Immumological aspects of kaolin-induced hydrocephalus
    Masaki Shinoda Lars Olson
    Int J Neurosci 92 9-28 1997 [Refereed]
  • Differential immune responses to fetal intracameral spinal cord and cortex cerebri grafts.
    Shinoda M, Giacobini M, Schmidt-Kastner R, Trok K, Olson L.
    Exp Brain Res 110(2) 223-234 Jul. 1996 [Refereed]
  • Interactions of neurotrophic factors GDNF and NT-3, but not BDNF, with the immune system following fetal spinal cord transplantation.
    Shinoda M, Hoffer BJ, Olson L
    Brain Res 722 153-167 May 1996 [Refereed]
  • Allogeneic grafts of fetal dopamine neurons: immunological reactions following active and adoptive immunizations.
    Shinoda M, Hudson JL, Strömberg I, Hoffer BJ, Moorhead JW, Olson L
    Brain Res 680 180-195 May 1995 [Refereed]
  • Detection of norepinephrine distribution in rats with adrenal medulla autotransplants using I-125 Meta-iodobenzyl guanidine.
    Shinoda M, Suzuki Y, Oi S, Tsugane R, Sato O
    Nucl Med Commun 15(9) 752-757 Sep. 1994 [Refereed]
  • Development of akinetic mutism and hyperphagia after left thalamic and right hypothalamic lesions.
    Shinoda M, Tsugu A, Oda S, Masuko A, Yamaguchi Tsuyoshi, Yamaguchi Tsutomu, Tsugane R, Sato O.
    Child's Nerv Syst 9(4) 243-245 Jul. 1993 [Refereed]
  • Single photon emission computerized tomography in childhood hydrocephalus.
    Shinoda M, Yamaguchi T, Tanaka Y, Sato O, Kobayashi S, Suzuki Y.
    Child's Nerv Syst 8(6) 219-221 Jun. 1992 [Refereed]


  • Guideline for Management and Treatment of Fetal & Congenital Hydrocephalus 2011 : COE-Fetal & Congenital Hydrocephalus Top 10 Japan Study Group
    OI Shizuo, INAGAKI Takayuki, NOMURA Sadahiro, DATE Isao, ONO Shigeki, SHINODA Masaki, TAKAHASHI Satoshi, MIWA Tomoru, ARAKI Takashi, ITO Susumu, UCHIKADO Hisaaki, TAKEMOTO Osamu, SHIRANE Reizo, NISHIMOTO Hiroshi, TASHIRO Yuzuru, MATSUMURA Akira
    小児の脳神経 36(2) 151-161 Apr. 2011
  • Guideline for Management and Treatment of Spina Bifida 2011 : COE-Spinal Lipoma Top 7 Japan Study Group
    OI Shizuo, NOMURA Sadahiro, DATE Isao, ONO Shigeki, SHINODA Masaki, TAKAHASHI Satoshi, SUZUKI Michiyasu, ARAI Hajime, NAGASAKA Masato, NISHIMOTO Hiroshi, SHIRANE Reizo, INAGAKI Takayuki, DATE Hiroaki
    小児の脳神経 36(1) 12-18 Feb. 2011
  • World's Studies of Hydrocephalus : Journal Review : Part 2 : Neuroendoscopic Surgery
    SHINODA Masaki, OI Shizuo
    小児の脳神経 34(4) 311-315 Aug. 2009
  • World's Studies of Hydrocephalus : Journal Reviews in the Beginning of This Century : Part 1 : Classical Concepts : Pathophysiology and CSF Shunt
    SHINODA Masaki, OI Shizuo
    小児の脳神経 33(6) 518-524 Dec. 2008
  • Neurotrophin-3 (NT-3) Administration Therapy for Experimental Hydrocephalus
    SHINODA Masaki, SAKABE Kou, TANAKA Yoshimi, HIDAKA Mitsuru, MATSUMAW Mitsunori, TSUGANE Ryuichi, OI Shizuo
    小児の脳神経 27(1) 7-10 Feb. 2002
  • Head Injured Children with Abuse and/ or Inappropriate Care
    SHINODA Masaki, TANAKA Hiroshi, KUMAZAWA Yoko, SUZUKI Isao, ODA Yoichiro, NISHIMURA Riki
    小児の脳神経 = Nervous System in Children 29(1) 8-13 Feb. 2004
  • Microglial Alterations in the Developing CNS
    SHINODA Masaki, SAKABE Kou, MUTO Hideo, MATSUMAE Mitsunori, HONDA Yumie, OI Shizuo, TSUGANE Ryuichi
    小児の脳神経 24(5) 453-456 Oct. 1999
  • Hydrocephalus and Neurotrophic Factors
    SHINODA Masaki, OI Shizuo, TSUGANE Ryuichi
    小児の脳神経 23(2) 86-95 Apr. 1998
  • Neuro-Vascular Developmental Interactions : Specific Forms of Vascular Maldevelopment in the Malformed Brain. Part 2. Fetal Cerebrovascular Diseases : Analysis of Clinical Cases
    Oi Shizuo, Tanaka Kei, Hidaka Mitsuru, Shinoda Masaki, Honda Yumie, Matsumae Mitsunori, Takei Futoshi, Sato Osamu, Matsumoto Satoshi, Nakagawa Yoshinobu
    Japanese journal of neurosurgery 5(6) 417-424 Nov. 1996
    The concept of cerebrovascular accident in the embryonal and fetal periods is obscure. It may affect neuronal development as an encephaloclastic insult in the later stages of development, although the specific critical period for this is completely unknown. Furthermore, vascular development may depend on the neuronal maturation process if the primary encephalodysplastic lesion occurs early in the development process. Various cases of cerebrovascular accident occurring in the fetal brain are summarized, and the specific nature of the disease is discussed in light of the relation between vascular development and the neuronal maturation process. Cerebrovascular diseases during the fetal period include intraventricular hemorrhage, ischemic lesions due to vascular occlusion occurring in monozygotic twins, various vessel abnormalities, etc. Cerebral dysgenetic malformations, on the other hand, result in a variety of developmental abnormalities of vascular structures. The present study emphasizes that the neuronal maturation process and vascular development may have a major effect upon each other depending upon the stage when the accident occurs in the fetal period. The authors describe this phenomenon in the fetal period as a specific etiopathophysiological entity : "neuro-vascular develop mental interaction".
  • Immunological reactions of neurotrophic factors administrated into striatum
    SHINODA Masaki, HOFFER Barry J., OLSON Lars, TSUGANE Ryuichi
    神経組織の成長・再生・移植 10(1) 77-78 Jun. 1998
  • Low-dose Dopamine Treatment of Patients in Nonketotic Hyperosmolar Hyperglycemic Coma
    SHIMODA Masami, YAMADA Shinya, SHINODA Masaki, ODA Shinri, HIDAKA Mitsuru, YAMAMOTO Isao, SATO Osamu, TSUGANE Ryuichi
    神経外科 29(10) 890-894 Oct. 1989
    In the acute neurosurgical setting, nonketotic hyperosmolar hyperglycemic coma (NHC) is thought to be caused by cerebral dehydration therapy and administration of steroids, glycerol, or mannitol. The mortality of this complication is reportedly very high, and is due to acute renal and/or cardiac failure. The authors evaluated the effect of low-dose dopamine (LDD; 1 to 5 μg/kg/min) administration in 10 patients with this syndrome. LDD was given to five patients. In these cases, hypovolemia was treated under central venous pressure monitoring with an iso-osmolar hyponatremic lactate solution given in a volume greater than the urine output. After the hypovolemia was corrected, the fluid was administered in a volume equal to the urine output until the serum osmolarity was normalized. In the five patients not given LDD, a large quantity of hypotonic solution was rapidly administered. In all patients treated with LDD, the urinary sodium increased and the urinary output stabilized. Consequently, the excess urea-nitrogen and serum sodium were quite easily washed out. The total net intake volume for the normalization of serum osmolarity was small and the duration of treatment was much shorter than that of patients not treated with LDD. The LDD regimen was not associated with complications, such as aggravation of cerebral edema, renal failure, or cardiac failure. On the other hand, three of the five patients not given LDD died of acute renal and/or cardiac failure without normalization of laboratory data. It is emphasized that this therapy, which results in β-effect of catecholamine, sodium diuresis, and increased renal blood flow, is a practical means of managing acute neurosurgical cases complicated by NHC.
  • Surgical Management of Cases with Internal Carotid Occlusion and Subarachnoid Hemorrhage from Vertebro-basilar Artery Aneurysms
    IKEDA Akira, YAMAMOTO Isao, SHINODA Masaki, SATO Osamu, SHIBUYA Masato, IGUCHI Ikuzo
    Surgery for Cerebral Stroke 16(1) 64-67 1988
    In patients with internal carotid artery occlusion, blood flow through the vertebro-basilar system and the posterior communicating artery as a collateral flow becomes much greater than the normal state, and aneurysms might be formed at these arteries as a result of increased hemodynamic stress, subsequently causing subarachnoid hemorrhage. The authors have experienced two such cases with asymptomatic carotid occlusion and ruptured vertebro-basilar artery aneurysms, including posterior communicating artery aneurysms. The first case, a 46-year-old female, had slowly progressive dementia for five years, prior to the episode of subarachnoid hemorrhage (SAH) of Hunt and Hess's grade III. A CT scan revealed moderate SAH, and a 4-vessel study angiography showed a left posterior cerebral-posterior communicating artery (P1-P2) aneurysm and a basilar-superior cerebellar artery aneurysm on the left side. Also it showed bilateral carotid artery occlusion in the neck, and the collateral flow from the left ophthalmic artery and the bilateral posterior cerebral arteries through the posterior communicating arteries was also documented. On the 20th day of SAH, an operation was performed. At first, superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis was performed on the right side which had less collateral flow than on the left side. This was followed by neck-clipping of the two aneurysms through the subtemporal route on the left side. Immediately after the operation, the patient had left hemispheric symptoms, though no major lesions were detected on the CT scan. Volume expansion and hypertensive therapy were started. On the third day, the revascularized area became low in density on the CT scan and it progressed into hemorrhage, resulting in tetraparesis and a vegetative state. This event could be explained by assuming that the so-called normal perfusion pressure breakthrough phenomenone from the bypass site occurred as a result of local hyperperfusion in chronically ischemic brain tissue under the postoperative control of volume expansion and hypertension.
    The second case, a 59-year-old male, had SAH of grade H, and angiography revealed a posterior cerebral-posterior communicating artery aneurysm with asymptomatic carotid occlusion in the cavernous portion, and a dominant collateral flow through the posterior communicating artery was also noted. After surviving a symptomatic vasospasm, STA-MCA anastomosis and neck-clipping of the aneurysm via fronto-temporal approach on the right side was uneventfully performed on the 21st day of SAH with a favorable outcome.
    In this paper, we discuss the mechanism of aneurysmal formation as a result of increased hemodynamic stress, and the operative procedures, including timing, that are necessary for safe operation. Finally, the pathogenesis of hemorrhage into the revascularized area seen in case one is discussed.
  • Curative Operations for Unclippable Aneurysms:-An application of microvascular suture technique-
    IKEDA Akira, YAMAMOTO Isao, TSUGANE Ryuichi, SHINODA Masaki, SHIMODA Masami, SATO Osamu
    Surgery for Cerebral Stroke 15(2) 166-170 1987
    The best treatment for intracranial aneurysms is undoubtedly neck-clipping; however, some aneurysms, such as giant aneurysms or those with a broad neck, cannot be treated in this manner. The microvascular suture technique introduced by Yasargil contributed to the wide indications for curative operations of some unclippable aneurysms.
    The authors present two cases of such unclippable aneurysms, which could be treated by utilizing the microvascular suture technique. The first case, a giant middle cerebral artery aneurysm, was managed with excision and end-to-end anastomosis, and the second case, an irregular shaped broadnecked aneurysm of the internal carotid artery, was treated by combining internal carotid trapping with an extracranial-intracranial bypass using an interposed saphenous vein graft. The patients had no postoperative neurological deficit. Alternative treatment is also discussed in this paper.
  • Efficacy of neuroendoscopic procedures in minimally invasive preferential management of pineal region tumors: a prospective study.
    Oi S, Shibata M, Tominaga J, Honda Y, Shinoda M, Takei F, Tsugane R, Matsuzawa K, Sato O.
    J Neurosurg 93 245-253 [Refereed]
  • Pathophysiology of long-standing overt ventriculomegaly in adults.
    Oi S, Shimoda M, Shibata M, Honda Y, Togo K, Shinoda M, Tsugane R, Sato O.
    J Neurosurg 92 933-940 [Refereed]

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