Tetsuya Sato

Faculty & Position:Center for Preventive Medicine  doctor
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Last Updated: Aug. 07, 2019 at 14:32

Research Activities

Misc

  • 禁煙後の体重変化に影響する要因の検討
    田中直彦, 横山剛義, 本間智美, 入澤裕子, 鶴谷麻木, 佐藤哲也, 中安邦夫
    人間ドック 31(2) 375 Jul. 2016
  • 肥満を改善したドック受検者の特徴
    田中直彦, 横山剛義, 本間智美, 入澤裕子, 鶴谷麻木, 菅原直子, 荒幡篤, 佐藤哲也, 高橋唯郎, 中安邦夫
    人間ドック 30(2) 495 Jul. 2015
  • 人間ドックにおける肺がん検診、胸部CTの役割について
    佐藤 哲也, 鈴木 一彦, 佐々木 清寿, 増田 勝紀, 負門 克典, 松迫 正樹, 栗原 泰之, 齋田 幸久
    日本がん検診・診断学会誌 22(1) 67-67 Jul. 2014
  • 安全な内視鏡検査実施の取り組み タイムアウトを導入して
    中野 まさも, 山中 まどか, 早坂 博子, 大高 純子, 包國 幸代, 亀田 綾, 甲屋 早苗, 増田 勝紀, 高島 みさ子, 佐藤 哲也
    総合健診 40(1) 201-201 Jan. 2013
  • 人間ドックにおける肺年齢活用の有用性
    深草 元紀, 遠藤 由理, 佐久間 葉子, 鈴木 一彦, 佐藤 哲也, 石田 也寸志, 増田 勝紀
    総合健診 40(1) 224-224 Jan. 2013
  • 当センターの胸部CT受検者の背景について
    佐藤 哲也, 鈴木 一彦, 河北 俊子, 負門 克典, 松迫 正樹, 齋田 幸久
    総合健診 39(1) 197-197 Jan. 2012
  • 人間ドック後の看護師による受診勧奨 健診を有効に活用していただくために
    新井 博子, 五十嵐 由衣, 宮内 留美, 山中 まどか, 甲屋 早苗, 加藤 明, 佐々木 清寿, 熊倉 泰久, 佐藤 哲也, 梅井 崇仁, 張 成斗, 河北 俊子
    総合健診 38(1) 164-164 Jan. 2011
  • 人間ドック後の看護師による受診勧奨を行って 健診を有効に活用していただくために
    宮内 留美, 新井 博子, 五十嵐 由衣, 山中 まどか, 甲屋 早苗, 加藤 明, 佐々木 清寿, 熊倉 泰久, 佐藤 哲也, 梅井 崇仁, 張 成斗, 河北 俊子
    総合健診 38(1) 165-165 Jan. 2011
  • 当センター人間ドックにおける禁煙支援の取り組みとその効果
    工藤 智子, 新井 博子, 亀田 綾, 佐々木 佳子, 下澤 麻子, 武藤 美穂, 柳橋 礼子, 包國 幸代, 佐藤 哲也, 鈴木 一彦, 林邊 晃, 諏訪 二郎, 河北 俊子
    総合健診 37(1) 190-190 Jan. 2010
  • 1日人間ドックでの禁煙支援
    佐藤 美香, 包國 幸代, 下澤 麻子, 新井 博子, 工藤 智子, 柳橋 礼子, 佐藤 哲也, 鈴木 一彦, 林邊 晃, 平松 園枝
    禁煙科学 3(1) 65-65 Apr. 2009
  • 生活習慣改善プログラム「禁煙サポートコース」の報告
    下澤 麻子, 包國 幸代, 佐藤 美香, 柳橋 礼子, 佐藤 哲也, 鈴木 一彦, 平松 園枝
    総合健診 35(1) 133-133 Jan. 2008
  • 胸部CT健診にて発見された肺切除症例の検討
    尾辻 瑞人, 大多和 正樹, 小野 宏, 蝶名林 直彦, 負門 克典, 松迫 正樹, 斎田 幸久, 深草 元紀, 佐藤 哲也, 林邉 晃, 平松 園枝
    総合健診 33(1) 161-161 Jan. 2006
  • 個人情報管理システムを用いた総合健診の実施(2) 医療情報の活用
    堀 三郎, 高橋 為生, 柳橋 礼子, 梅井 崇仁, 玉木 真一, 増田 勝紀, 佐藤 春美, 林邉 晃, 深草 元紀, 佐藤 哲也, 日下 敦子, 新里 理香, 岡田 昌子, 吉田 智峰子
    総合健診 32(1) 203-203 Jan. 2005
  • 聖路加国際病院附属クリニック・予防医療センターにおける16列MDCTによる肺癌検診の初期経験
    松迫 正樹, 負門 克典, 深草 元紀, 林邉 晃, 佐藤 哲也, 堀 三郎, 沼口 雄治
    胸部CT検診 12(1) 63-64 Jan. 2005
  • 人間ドックにおける睡眠時無呼吸症候群症例の発見意義
    佐藤 哲也, 吉田 智峰子, 岡田 昌子, 新里 理香, 日下 敦子, 奥村 太郎, 堀 三郎
    健康医学 19(2) 336-336 Aug. 2004
  • 人間ドックにおける5年連続受診者の検査値についての検討
    日下 敦子, 岡田 昌子, 新里 理香, 佐藤 哲也, 奥村 太郎, 日野原 茂雄, 堀 三郎
    総合健診 31(1) 363-363 Jan. 2004
  • Posthyperventilation hypoxemia after methacholine inhalation
    Tateo Ogura, Hirosuke Kobayashi, Hirosuke Kobayashi, Michihiro Suzuki, Tetsuya Sato, Tomoyuki Tomita
    Japanese Journal of Physiology 48 39-47 Jan. 1998
    The hypothesis of this study was that hypoxemia after methacholine (MTH) inhalation is related not only to ventilation/perfusion inhomogeneity, but also to posthyperventilation hypoxemia. To test the hypothesis, we paid special attention to changes in gas exchange and ventilation parameters after MTH inhalation. Six stable asthma patients were investigated, and Sa(O2), minute ventilation (̇E), oxygen uptake rate in the lung (̇O2), carbon dioxide output rate in the lung (̇CO2), and respiratory exchange ratio (R) were measured. The Sa(O2) level decreased from a baseline level (before MTH inhalation) of 96.8±1.0% (mean±SD) to the lowest level (the nadir Sa(O2) of 89.8±2.1% (p<0.01) in 200±50 s after MTH inhalation and gradually increased toward the baseline level. ̇CO2increased just after MTH inhalation (post-MTH) with increased ̇E, and decreased at the nadir Sa(O2) with baseline ̇E and Pa(CO2), indicating a decrease in breath-by-breath ̇A and an increase in dead space minute ventilation at the nadir Sa(O2), but ̇O2remained close to constant. R increased post-MTH, decreased at the nadir Sa(O2), and thereafter increased gradually toward the baseline level with a time constant of 5.6 min. The addition of CO2to inspired air partially suppressed hypoxemia. The consensus is that hypoxemia after MTH is solely attributable to the ventilation/perfusion inhomogeneity, but posthyperventilation hypoxemia is another reasonable interpretation of the hypoxemia after MTH with decreased ̇A, ̇CO2, and R. It is speculated that posthyperventilation normoventilation in respect to ̇CO2with baseline Pa(CO2) after MTH inhalation resulted in posthyper- ventilation hypoxemia as a result of relative hypoventilation in respect to ̇O2.
  • Nitrosyl hemoglobin in blood of normoxic and hypoxic sheep during nitric oxide inhalation
    Yuko Takahashi, Hirosuke Kobayashi, Hirosuke Kobayashi, Naohiko Tanaka, Tetsuya Sato, Naosada Takizawa, Tomoyuki Tomita
    American Journal of Physiology - Heart and Circulatory Physiology 274 Jan. 1998
    During nitric oxide (NO) inhalation therapy, NO combines with deoxyhemoglobin to form nitrosyl hemoglobin (HbNO). We used electron spin resonance (ESR) spectroscopy to measure HbNO in arterial and mixed venous blood of normoxic and hypoxic sheep during NO inhalation. Our aim was to quantitatively measure HbNO levels in the blood during NO inhalation, because large amounts of HbNO reduce the oxygen capacity of blood, particularly in hypoxia. Another aim was to investigate the transfer of exogenous NO to the α-heme iron of hemoglobin. Thirteen sheep were anesthetized with pentobarbital sodium, and 60 parts per million (ppm) NO were administered for 1 h in the presence of normoxia and hypoxia. Two-way analysis of variance revealed that the HbNO level was dependent on the oxygen level (normoxia vs. hypoxia) and NO inhalation, and there was a significant negative correlation between the HbNO level and arterial O2 saturation (SaO2). Although the HbNO level increased during NO inhalation in hypoxia, the HbNO level at SaO2 >60% was <11 μmol/l monomer hemoglobin (0.11% of total 10 mmol/l monomer hemoglobin). The peak of the HbNO ESR spectrum in arterial blood is located in almost the same position in mixed venous blood with an asymmetric HbNO signal, indicating that the NO in β-heme HbNO molecules had been transferred to α-heme molecules. The three-line hyperfine structure of HbNO on ESR spectra was distinct in venous blood in hypoxia during NO inhalation, indicating pentacoordinate α-NO heme formation in hypoxic blood. In conclusion, the amount of HbNO during 60 ppm NO inhalation did not considerably reduce the oxygen capacity of the blood even in the presence of hypoxia, and the NO of HbNO was transferred to the α-heme iron of hemoglobin, forming pentacoordinate α-NO heme in mixed venous blood in hypoxia.
  • Nitrosyl hemoglobin in blood of normoxic and hypoxic sheep during nitric oxide inhalation
    Yuko Takahashi, Hirosuke Kobayashi, Hirosuke Kobayashi, Naohiko Tanaka, Tetsuya Sato, Naosada Takizawa, Tomoyuki Tomita
    American Journal of Physiology - Heart and Circulatory Physiology 43 Jan. 1998
    During nitric oxide (NO) inhalation therapy, NO combines with deoxyhemoglobin to form nitrosyl hemoglobin (HbNO). We used electron spin resonance (ESR) spectroscopy to measure HbNO in arterial and mixed venous blood of normoxic and hypoxic sheep during NO inhalation. Our aim was to quantitatively measure HbNO levels in the blood during NO inhalation, because large amounts of HbNO reduce the oxygen capacity of blood, particularly in hypoxia. Another aim was to investigate the transfer of exogenous NO to the α-heme iron of hemoglobin. Thirteen sheep were anesthetized with pento-barbital sodium, and 60 parts per million (ppm) NO were administered for 1 h in the presence of normoxia and hypoxia. Two-way analysis of variance revealed that the HbNO level was dependent on the oxygen level (normoxia vs. hypoxia) and NO inhalation, and there was a significant negative correlation between the HbNO level and arterial O2 saturation (SaO2). Although the HbNO level increased during NO inhalation in hypoxia, the HbNO level at SaO2 >60% was <11 μmol/l monomer hemoglobin (0.11% of total 10 mmol/l monomer hemoglobin). The peak of the HbNO ESR spectrum in arterial blood is located in almost the same position in mixed venous blood with an asymmetric HbNO signal, indicating that the NO in β-heme HbNO molecules had been transferred to α-heme molecules. The three-line hyperfine structure of HbNO on ESR spectra was distinct in venous blood in hypoxia during NO inhalation, indicating pentacoordinate α-NO heme formation in hypoxic blood. In conclusion, the amount of HbNO during 60 ppm NO inhalation did not considerably reduce the oxygen capacity of the blood even in the presence of hypoxia, and the NO of HbNO was transferred to the α-heme iron of hemoglobin, forming pentacoordinate α-NO heme in mixed venous blood in hypoxia. Copyright © 1998 the American Physiological Society.
  • 急性間質性肺炎を合併したHTLV-Iキャリアーの1例
    佐藤 哲也
    神奈川県感染症研究会抄録集 31回-36回 29-29 Sep. 1997
  • Pulmonary Actinomycosis Resembling an Anterior Mediastinal Tumor
    SATO Tetsuya, TAKADA Nobukazu, DOBASHI Yukari, SUZUKI Mitsuko, OUCHI Motofumi, ABE Yoshiaki
    日本胸部疾患学会雑誌 = The Japanese journal of thoracic diseases 35(8) 888-893 Aug. 1997
  • Erythropoietin and base excess levels in patients with chronic pulmonary diseases
    Hirosuke Kobayashi, Tetsuya Sato, Nobukazu Takada, Tomoyuki Tomita
    Respiration Physiology 107 37-45 Jan. 1997
    Factors which could influence serum erythropoietin (s-EPO) levels in patients with chronic pulmonary diseases were investigated, paying special attention to the role of changes in acid-base balance (Pa(CO2), HCO3-and base excess levels) in EPO production. Data from 30 patients with chronic pulmonary diseases (chronic pulmonary emphysema, chronic bronchitis and post-tuberculosis status) were obtained in the morning and were analyzed with a stepwise forward multiple regression analysis, evaluating the statistical significance of seven factors which may potentially influences-EPO levels: arterial pH, Pa(CO2), Pa(O2), HCO3-, base excess (BE), Sa(O2) and hemoglobin (Hb). Significant simple correlations (P < 0.01) of log(s-EPO) were obtained with Pa(O2) (r = -0.66), Pa(CO2) (r = 0.59), HCO3-(r = 0.67), BE (r = 0.71) and Sa(O2) (r = -0.77). The stepwise forward multiple regression analysis revealed that significant correlate variables for the outcome variable of log(s-EPO) were Sa(O2) and BE, with r = 0.823 (P < 0.0001). In patients with chronic pulmonary diseases it was shown that Sa(O2) was a negative correlate and BE was a positive correlate of s-EPO levels. It was speculated that s-EPO levels in the morning reflected daytime hypoxemia (Sa(O2)) and nocturnal desaturation evoked by hypopnea during sleep (indicated as BE) in these patients.
  • Pulmonary Actinomycosis Resembling an Anterior Mediastinal Tumor.
    Sato Tetsuya, Takada Nobukazu, Dobashi Yukari, Suzuki Mitsuko, Ouchi Motofumi, Abe Yoshiaki
    The Japanese journal of thoracic diseases 35(8) 888-893 1997
    A 25-year-old, previously healthy man was referred to us because of fever, left-sided chest pain, and an abnormal mass shadow at the left pulmonary hilum on chest X-ray films. Laboratory tests and fiberoptic bronchoscopy revealed no abnormality. Thoracotomy was done because a mediastinal tumor was suspected. Surgery revealed that the left lingula was atelectatic and that the mass was in the left S4, not in the mediastinum. Pathological examination of tissue from the partially resected lung showed sulfur granules, and a diagnosis of pulmonary actinomycosis was made. At least 80 cases of pulmonary actinomycosis were reported in Japan between 1963 and 1995. Pulmonary actinomycosis is most common among men in the fifth and sixth decades of life, and almost all patients have oral disease. Pulmonary actinomycosis is often difficult to distinguish from lung cancer, because both appear as mass shadows on X-ray films, and almost all cases of pulmonary actinomycosis are diagnosed by thoracotomy.
  • [Basic evaluation of nitric oxide inhalation therapy].
    Kobayashi H, Takahashi Y, Mitsufuji H, Sato T, Tanaka N, Hirose M, Soma K, Tomita T
    Nihon Kyobu Shikkan Gakkai zasshi 33 Suppl 193-198 Dec. 1995 [Refereed]
  • 前縦隔腫瘍との鑑別を要した肺放線菌症の1例 本邦80例の臨床的集計
    佐藤 哲也, 高田 信和, 土橋 ゆかり
    日本胸部疾患学会雑誌 35(8) 888-893 Aug. 1997
    25歳男,発熱及び左胸部痛にて受診し,胸部X線写真で左肺門部に腫瘤影を認めた.諸検査にても確定診断に至らず,画像上前縦隔腫瘍が疑われ,開胸手術を行った.開胸時,舌区は無気肺になっており,腫瘤は前縦隔ではなく左S4に存在し,同部を楔状切除した.切除肺の病理組織標本で硫黄顆粒を認め,肺放線菌症と診断した.本邦における肺放線菌症報告例は,1963〜1995年の間に80例あり,特に1980年以降は漸増傾向にある.40〜50歳代の男性に好発し,口腔内病変との合併が多く,胸部X線写真では腫瘤影を呈する例が多い等の特徴が認められた.また,開胸手術による病理学的検索にて,初めて確定診断に至る例が多かった
  • 吸入気酸素濃度と肺の一酸化窒素(NO)吸収量および吸入効果との関係
    佐藤 哲也
    日本胸部疾患学会雑誌 33(増刊) 112-112 Mar. 1995
  • 低濃度酸素負荷中の家兎における一酸化窒素吸入濃度と肺動脈圧および動脈血酸素分圧との濃度・反応関係の検討
    佐藤 哲也, 小林 弘祐, 田中 直彦
    呼吸 14(1) 63-71 Jan. 1995
    ウサギ11羽に吸入気酸素濃度(FIO2) 0.13〜0.15の低酸素を吸入させ(baseline),異なる濃度のNO (1〜80ppm)を吸入させた。平均肺動脈圧(mPAP)は濃度依存性に低下し,80ppmでbaselineとの差が-4.4±1.2mmHgと最低値であったが,平均体血圧に変化はなかった。各NO吸入濃度の動脈血酸素分圧(Pao2)とbaselineのPao2との差(ΔPao2)が20ppmで7Torr以上改善した対象例(A群)では,ΔPao2が20ppmで18.6±7.0Torr増加し最高値となったが,それ以上のNO濃度では逆に増加分は減少した。肺胞気・動脈血酸素分圧較差(A-aDo2)も20ppmでbaselineに比べて12.6±9.9Torr減少した。ΔPao2が20ppmで7Torrに満たなかった対象例(B群)ではNO吸入によっても,A-aDo2の改善がなかった
  • 5ppmの一酸化窒素吸入にて酸素化能の改善をみたARDS症例
    田中 直彦, 小林 弘祐, 佐藤 哲也
    日本胸部疾患学会雑誌 32(12) 1187-1193 Dec. 1994
  • 一酸化窒素吸入による肺動脈圧および動脈血液ガスの濃度 反応関係について
    佐藤 哲也
    日本胸部疾患学会雑誌 32(増刊) 205-205 Mar. 1994
  • A Case of Aspirin-Induced Asthma which Developed Due to Rubbing a Lotion Containing a Non-Steroidal Anti-Inflammatory Drug, Ketoprofen, on the Skin.
    Tanaka Naohiko, Kobayashi Hirosuke, Mitsufuji Hisashi, Sato Tetsuya, Ogura Tateo, Takada Nobukazu, Abe Tadashi, Tomita Tomoyuki
    The Japanese journal of thoracic diseases 32(4) 378-381 1994
    A forty-year-old woman was admitted to our hospital because of a severe attack of bronchial asthma. The asthmatic attack developed 3 hours after her rubbing a large amount of a lotion containing a non-steroidal antiinflammatory drug (NSAID), ketoprofen, over her skin. The patient had a past history of asthmatic attack induced by another NSAID (Sedes-G®) given per os. The previous asthmatic attack developed about 20 minutes after she was given the NSAID per os, but the presently reported attack developed about 3 hours after her rubbing the lotion containing the NSAID over her skin. The relatively long interval between the per cutaneous NSAID administration and the onset of the asthmatic attack indicates that the time delay is dependent on the absorption route of the adminisered NSAID. The severity of the attack is considered to be related to the amount of NSAID absorbed.
  • ラットにおける低酸素負荷時の肺細動脈径の変化
    田中 直彦, 小林 弘祐, 佐藤 哲也
    臨床呼吸生理 25(2) 173-175 Nov. 1993
    1)低酸素負荷時に動脈の比較的太い部分では明らかな変化はみられなかったが,比較的細い部分で血管径の減少がみられた。2)すべての測定点での低酸素負荷前後の血管径の比と室内気換気時の血管径との関係をみた。室内気による換気時の血管径が細い部位で,低酸素負荷時に血管径はより細く変化していた。3)動脈を室内気による換気時の血管径で20μm未満,20μm以上30μm以下,31μm以上60μm以下の3群に分け,それぞれの低濃度酸素負荷前後の血管径の比を比べた。動脈側では20μm未満の群で血管径に平均10%の減少がみられ,統計学的に有意な減少であった。以上,ラットにおける低酸素負荷時の微小循環レベルでの変化は,20μm未満の動脈の部位に認められた
  • メサコリン吸入中の呼気ガスおよび動脈血酸素飽和度の経時的測定
    佐藤 哲也
    日本胸部疾患学会雑誌 31(増刊) 304-304 Mar. 1993
  • 急性間質性肺炎を合併したHTLV-1キャリアーの1例
    佐藤 哲也
    日本内科学会関東地方会抄録集(4) 66-66 Mar. 1993
  • 慢性肺疾患患者における血清エリスロポイエチン値について
    佐藤 哲也
    臨床病理 40(補冊) 149-149 Aug. 1992
  • 慢性閉塞性肺疾患患者における血清エリスロポイエチン値について
    佐藤 哲也
    日本胸部疾患学会雑誌 30(増刊) 215-215 Apr. 1992
  • 気道過敏性検査中の酸素飽和度の検討
    楠原 範之, 佐藤 哲也, 田中 直彦
    臨床呼吸生理 23(2) 157-162 Nov. 1991
    呼吸抵抗を用いた気道過敏性検査において,頸部呼吸音とともにSaO2をモニターすることは,検査をより安全に行う上で有用である


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