YAMAMOTO Hiroyuki

Faculty & Position:Nephrology Department  doctor
Contact:
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Last Updated: Jul. 21, 2020 at 05:04

Researcher Profile & Settings

Association Memberships

    , Japanese Society for Dialysis Therapy

Research Activities

Research Areas

  • Life sciences / Healthcare management, medical sociology
  • Life sciences / Hygiene and public health (non-laboratory)
  • Life sciences / Nephrology

Research Interests

    Dialysis therapy , CKD , Clinical Epidemiology , Nephrology

Published Papers

  • Patient trends and outcomes of surgery for type A acute aortic dissection in Japan: an analysis of more than 10 000 patients from the Japan Cardiovascular Surgery Database.
    Tomonobu Abe, Hiroyuki Yamamoto, Hiroaki Miyata, Noboru Motomura, Yoshiyuki Tokuda, Kazuo Tanemoto, Akihiro Usui, Shinichi Takamoto
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 57(4) 660-667 Apr. 2020 [Refereed]
    OBJECTIVES: To evaluate the background trends and surgical outcomes for more than 10 000 patients with acute type A dissection in Japan in a recent 8-year period. METHODS: Data on replacement of the ascending aorta and/or aortic arch for acute type A dissection were collected from the Japan Cardiovascular Surgery Database from 2008 to 2015. Linear-by-linear association tests or Cuzick's test for trend was used to evaluate group trends over time. The results were calculated for ascending or hemiarch replacement and arch replacement. A multivariable logistic regression model was used to calculate the risk-adjusted operative mortality rate. RESULTS: A total of 11 843 patients were included. The overall 30-day mortality and operative mortality rates were 7.6% and 9.5%, respectively. The number of surgically treated cases increased from 2436 patients in 2008-2009 to 3533 in 2014-2015, a 45.0% increase. A trend analysis revealed significant changes in patient characteristics with time, including increasing age and rate of preoperative renal failure. Despite worsening risk factors, the unadjusted operative mortality rate with arch replacement showed a significant downward trend (P = 0.01; test of trend). The risk-adjusted mortality rate showed a downward trend both in ascending aorta or hemiarch replacement and arch replacement, although the trend was not statistically significant (P > 0.05). CONCLUSIONS: Unadjusted and adjusted operative deaths have shown a decreasing trend, although patients undergoing surgery for acute type A dissection have demonstrated worsening of risk factors, such as age and renal failure. The number of surgeries performed for acute type A dissection significantly increased throughout the study period in Japan.
  • Significance of the board-certified surgeon systems and clinical practice guideline adherence to surgical treatment of esophageal cancer in Japan: a questionnaire survey of departments registered in the National Clinical Database.
    Toh Y, Yamamoto H, Miyata H, Gotoh M, Watanabe M, Matsubara H, Kakeji Y, Seto Y
    Esophagus : official journal of the Japan Esophageal Society 16(4) 362-370 Apr. 2019 [Refereed]
    BACKGROUND: It remains unknown how much institutional medical structure and process of implementation of clinical practice guidelines for esophageal cancers can improve quality of surgical outcome in Japan. METHODS: A web-based questionnaire survey was performed for departments registered in the National Clinical Database in Japan from October 2014 to January 2015. Quality indicators (QIs) including structure and process indicators (clinical practice guideline adherence) were evaluated on the risk-adjusted odds ratio for operative mortality (AOR) of the patients using registered cases in the database who underwent esophagectomy and reconstruction in 2013 and 2014. RESULTS: Among 916 departments which registered at least one esophagectomy case during the study period, 454 departments (49.6%) responded to the questionnaire. Analyses of 6661 cases revealed that two structure QIs (certification of training hospitals by Japan Esophageal Society and presence of board-certified esophageal surgeons) were associated with significantly lower AOR (p < 0.001 and p = 0.005, respectively). One highly recommended process QI regarding preoperative chemotherapy had strong tendency to associate with lower AOR (p = 0.053). In two process QIs, the answer "performed at the doctor's discretion" showed a significant negative impact on prognosis, suggesting importance of institutional uniformity. CONCLUSIONS: The medical institutional structure of board-certified training sites for esophageal surgeons and of participation of board-certified esophageal surgeons improves surgical outcome in Japan. Establishment of appropriate QIs and their uniform implementation would be crucial for future quality improvement of medical care in esophagectomy.
  • Effect of hospital and surgeon volume on postoperative outcomes after distal gastrectomy for gastric cancer based on data from 145,523 Japanese patients collected from a nationwide web-based data entry system.
    Iwatsuki M, Yamamoto H, Miyata H, Kakeji Y, Yoshida K, Konno H, Seto Y, Baba H
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 22(1) 190-201 Oct. 2018 [Refereed]
    BACKGROUND: Despite interest in surgeon and hospital volume effects on distal gastrectomy, clinical significance has not been confirmed in a large-scale population. We studied to clarify the effects of surgeon and hospital volume on postoperative mortality after distal gastrectomy for gastric cancer among Japanese patients in a nationwide web-based data entry system. METHODS: We extracted data on distal gastrectomy for gastric cancer from the National Clinical Database between 2011 and 2015. The primary outcome was operative mortality. Hospital volume was divided into 3 tertiles: low (1-22 cases per year), medium (23-51) and high (52-404). Surgeon volume was divided into the 5 groups: 0-3, 4-10, 11-20, 21-50, 51 + cases per year. We calculated the 95% confidence interval (CI) for the mortality rate based on odds ratios (ORs) estimated from a hierarchical logistic regression model. RESULTS: We analyzed 145,523 patients at 2182 institutions. Operative mortality was 1.9% in low-, 1.0% in medium- and 0.5% in high-volume hospitals. The operative mortality rate decreased definitively with surgeon volume, 1.6% in the 0-3 group and 0.3% in the 51 + group. After risk adjustment for surgeon and hospital volume and patient characteristics, hospital volume was significantly associated with operative morality (medium: OR 0.64, 95% CI 0.56-0.73, P < 0.001; high: OR 0.42, 95% CI 0.35-0.51, P < 0.001). CONCLUSIONS: We demonstrate that hospital volume can have a crucial impact on postoperative mortality after distal gastrectomy compared with surgeon volume in a nationwide population study. These findings suggest that centralization may improve outcomes after distal gastrectomy.
  • Association of Circulatory Iron Deficiency With an Enlarged Heart in Patients With End-Stage Kidney Disease.
    Hayashi T, Tanaka Y, Iwasaki M, Hase H, Yamamoto H, Komatsu Y, Ando R, Ikeda M, Inaguma D, Sakaguchi T, Shinoda T, Koiwa F, Negi S, Yamaka T, Shigematsu T, Joki N
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 29(1) 39-47 Aug. 2018 [Refereed]
  • Validity and significance of 30-day mortality rate as a quality indicator for gastrointestinal cancer surgeries.
    Mizushima T, Yamamoto H, Marubashi S, Kamiya K, Wakabayashi G, Miyata H, Seto Y, Doki Y, Mori M
    Annals of gastroenterological surgery 2(3) 231-240 Apr. 2018 [Refereed]
    Background and Aim: Benchmarking has proven beneficial in improving the quality of surgery. Mortality rate is an objective indicator, of which the 30-day mortality rate is the most widely used. However, as a result of recent advances in medical care, the 30-day mortality rate may not cover overall surgery-related mortalities. We examined the significance and validity of the 30-day mortality rate as a quality indicator. Methods: The present study was conducted on cancer surgeries of esophagectomy, total gastrectomy, distal gastrectomy, right hemicolectomy, low anterior resection, hepatectomy, and pancreaticoduodenectomy that were registered in the first halves of 2012, 2013 and 2014 in a Japanese nationwide large-scale database. This study examined the mortality curve for each surgical procedure, "sensitivity of surgery-related death" (capture ratio) at each time point between days 30-180, and the association between mortality within 30 days, mortality after 31 days, and preoperative, perioperative, and postoperative factors. Results: Surgery-related mortality rates of each surgical procedure were 0.6%-3.0%. Regarding 30-day mortality rates, only 38.7% (esophagectomy) to 53.3% (right hemicolectomy) of surgery-related mortalities were captured. The capture ratio of surgery-related deaths reached 90% or higher for 120-day to 150-day mortality rates. Factors associated with mortality rate within 30 days/after the 31st day were different, depending on the type of surgical procedure. Conclusion: Thirty-day mortality rate is useful as a quality indicator, but is not necessarily sufficient for all surgical procedures. Quality of surgery may require evaluation by combining 30-day mortality rates with other indicators, depending on the surgical procedure.
  • Association between institutional procedural preference and in-hospital outcomes in laparoscopic surgeries; Insights from a retrospective cohort analysis of a nationwide surgical database in Japan.
    Miyata H, Mori M, Kokudo N, Gotoh M, Konno H, Wakabayashi G, Matsubara H, Watanabe T, Ono M, Hashimoto H, Yamamoto H, Kumamaru H, Kohsaka S, Iwanaka T
    PloS one 13(3) e0193186 2018 [Refereed]
  • Incidence of and risk factors for newly diagnosed hyperkalemia after hospital discharge in non-dialysis-dependent CKD patients treated with RAS inhibitors.
    Saito Y, Yamamoto H, Nakajima H, Takahashi O, Komatsu Y
    PloS one 12(9) e0184402 2017 [Refereed]
    Introduction Renin-angiotensin system (RAS) inhibitors have been increasingly prescribed due to their beneficial effects on end-organ protection. Iatrogenic hyperkalemia is a well-known life-threatening complication of RAS inhibitor use in chronic kidney disease (CKD) patients. We hypothesized that CKD patients treated with RAS inhibitors frequently develop hyperkalemia after hospital discharge even if they were normokalemic during their hospitalization because their lifestyles change substantially after discharge. The present study aimed to examine the incidence of newly diagnosed hyperkalemia, the timing of hyperkalemia, and its risk factors in CKD patients treated with RAS inhibitors at the time of hospital discharge. Methods We retrospectively enrolled patients aged 20 years or older with CKD G3-5 (estimated glomerular filtration rate < 60 mL/min/1.73 m(2)) and who were treated with RAS inhibitors and discharged from St. Luke's International Hospital between July 2011 and December 2015. Patients who were under maintenance dialysis or had hyperkalemic events before discharge were excluded. Data regarding the patients' age, sex, CKD stage, diabetes mellitus status, malignancy status, combined use of RAS inhibitors, concurrent medication, and hyperkalemic events after discharge were extracted from the hospital database. Our primary outcome was hyperkalemia, defined as serum potassium >= 5.5 mEq/L. Multiple logistic regression and Kaplan-Meier analyses were performed to identify the risk factors for and the timing of hyperkalemia, respectively. Results Among the 986 patients, 121 (12.3%) developed hyperkalemia after discharge. In the regression analysis, relative to CKD G3a, G3b [odds ratio (OR): 1.88, 95% confidence interval 1.20-2.97] and G4-5 (OR: 3.40, 1.99-5.81) were significantly associated with hyperkalemia. The use of RAS inhibitor combinations (OR: 1.92, 1.19-3.10), malignancy status (OR: 2.10, 1.14-3.86), and baseline serum potassium (OR: 1.91, 1.23-2.97) were also significantly associated with hyperkalemia. The Kaplan-Meier analysis showed that hyperkalemia was most frequent during the early period after discharge, particularly within one month. Conclusion Hyperkalemia was frequent during the early period after discharge among previously normokalemic CKD patients who were treated with RAS inhibitors. Appropriate follow-up after discharge should be required for these patients, particularly those with advanced CKD or malignancy status, such as hematological malignancy or late-stage malignancy, and those who are treated with multiple RAS inhibitors.
  • Relationship between hospital volume and hemorrhagic complication after percutaneous renal biopsy: results from the Japanese diagnosis procedure combination database.
    Yamamoto H, Hashimoto H, Nakamura M, Horiguchi H, Yasunaga H
    Clinical and experimental nephrology 19(2) 271-277 Apr. 2015 [Refereed]
    Although hemorrhagic complications are major complications of percutaneous renal biopsy (PRB), the relationship between procedure volume and morbidity remains unclear for PRB. The present study investigated the impact of hospital volume on the occurrence of hemorrhagic complications after PRB. Using large claims-based data in the diagnosis procedure combination database in Japan, we identified inpatients with renal disorders who underwent PRB within 4 days after admission during July to December 2007 to 2010. We assessed patient age, sex, clinical syndromes, hemorrhagic complications and diagnoses, and annual hospital volume of PRB divided into quintiles. Multivariate logistic regression analyses fitted with a generalized estimation equation were performed accounting for within-hospital clustering. A total of 15,191 patients were identified from 942 hospitals. The overall proportion of hemorrhagic complications was 2.1 %, including diagnoses of hemorrhagic events (1.6 %), red blood cell transfusion (0.5 %), and requiring angiography or endovascular procedure (0.1 %). In-hospital deaths attributable to the complications occurred in 0.06 % of the patients. Patients with rapidly progressive nephritic syndrome (odds ratio 3.41, 95 % confidence interval 2.22-5.25) had significantly higher incidence than those with chronic nephritic syndrome. No significant association was observed between hospital volume and hemorrhagic complications, with odds ratios for the low-intermediate, intermediate, intermediate-high, and high-volume groups relative to the low-volume group of 0.74 (0.43-1.26), 1.19 (0.74-1.92), 1.16 (0.67-2.00), and 1.35 (0.78-2.34), respectively. No significant relationship was observed between hemorrhagic complication incidence and hospital volume regarding PRB.
  • Dynamic subcellular localization of aquaporin-7 in white adipocytes.
    Miyauchi T, Yamamoto H, Abe Y, Yoshida GJ, Rojek A, Sohara E, Uchida S, Nielsen S, Yasui M
    FEBS letters 589(5) 608-614 Feb. 2015 [Refereed]
    Aquaporin-7 (AQP7) is expressed in adipose tissue, permeated by water and glycerol, and is involved in lipid metabolism. AQP7-null mice develop obesity, insulin resistance, and adipocyte hypertrophy. Here, we show that AQP7 is expressed in adipocyte plasma membranes, and is re-localized to intracellular membranes in response to catecholamine in mouse white adipose tissue. We found that internalization of AQP7 was induced by PKA activation and comparative gene identification 58 (CGI-58). This relocation was confirmed by functional studies in 3T3-L1 adipocytes. Collectively, these results suggest that AQP7 makes several contributions to adipocyte metabolism, in both cortical and intracellular membranes. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
  • Modified Cut-Off Value of the Urine Protein-To-Creatinine Ratio Is Helpful for Identifying Patients at High Risk for Chronic Kidney Disease: Validation of the Revised Japanese Guideline.
    Yamamoto H, Yamamoto K, Yoshida K, Shindoh C, Takeda K, Monden M, Izumo H, Niinuma H, Nishi Y, Niwa K, Komatsu Y
    The Tohoku journal of experimental medicine 237(3) 201-207 2015 [Refereed]
    Chronic kidney disease (CKD) is a global public health issue, and strategies for its early detection and intervention are imperative. The latest Japanese CKD guideline recommends that patients without diabetes should be classified using the urine protein-to-creatinine ratio (PCR) instead of the urine albumin-to-creatinine ratio (ACR); however, no validation studies are available. This study aimed to validate the PCR-based CKD risk classification compared with the ACR-based classification and to explore more accurate classification methods. We analyzed two previously reported datasets that included diabetic and/or cardiovascular patients who were classified into early CKD stages. In total, 860 patients (131 diabetic patients and 729 cardiovascular patients, including 193 diabetic patients) were enrolled. We assessed the CKD risk classification of each patient according to the estimated glomerular filtration rate and the ACR-based or PCR-based classification. The use of the cut-off value recommended in the current guideline (PCR 0.15 g/g creatinine) resulted in risk misclassification rates of 26.0% and 16.6% for the two datasets. The misclassification was primarily caused by underestimation. Moderate to substantial agreement between each classification was achieved: Cohen's kappa, 0.56 (95% confidence interval, 0.45-0.69) and 0.72 (0.67-0.76) in each dataset, respectively. To improve the accuracy, we tested various candidate PCR cut-off values, showing that a PCR cut-off value of 0.08-0.10 g/g creatinine resulted in improvement in the misclassification rates and kappa values. Modification of the PCR cut-off value would improve its efficacy to identify high-risk populations who will benefit from early intervention.
  • The total urine protein-to-creatinine ratio can predict the presence of microalbuminuria.
    Yamamoto K, Yamamoto H, Yoshida K, Niwa K, Nishi Y, Mizuno A, Kuwabara M, Asano T, Sakoda K, Niinuma H, Nakahara F, Takeda K, Shindoh C, Komatsu Y
    PloS one 9(3) e91067 Mar. 2014 [Refereed]
    Background: The Kidney Disease: Improving Global Outcomes chronic kidney disease (CKD) guidelines recommend that CKD be classified based on the etiology, glomerular filtration rate (GFR) and degree of albuminuria. The present study aimed to establish a method that predicts the presence of microalbuminuria by measuring the total urine protein-to-creatinine ratio (TPCR) in patients with cardiovascular disease (CVD) risk factors. Methods and Results: We obtained urine samples from 1,033 patients who visited the cardiovascular clinic at St. Luke's International Hospital from February 2012 to August 2012. We measured the TPCR and the urine albumin-to-creatinine ratio (ACR) from random spot urine samples. We performed correlation, receiver operating characteristic (ROC) curve, sensitivity, and subgroup analyses. There was a strong positive correlation between the TPCR and ACR (R-2 = 0.861, p < 0.001). A ROC curve analysis for the TPCR revealed a sensitivity of 94.4%, a specificity of 86.1%, and an area under the curve of 0.903 for detecting microalbuminuria for a TPCR cut-off value of 84 mg/g of creatinine. The subgroup analysis indicated that the cut-off value could be used for patients with CVD risk factors. Conclusions: These results suggest that the TPCR with an appropriate cut-off value could be used to screen for the presence of microalbuminuria in patients with CVD risk factors. This simple, inexpensive measurement has broader applications, leading to earlier intervention and public benefit.
  • Renal Function and Mortality in Patients with Infective Endocarditis
    Nishizaki Yuji, Watanabe Takuya, Tokuda Yasuharu, Futatsuyama Miyuki, Furukawa Keiichi, Mori Nobuyoshi, Tsugawa Yusuke, Yuki Heath, Tamagaki Keiichi, Taki Fumika, Yamamoto Hiroyuki, Ohiwa Takafumi, Komatsu Yasuhiro
    General Medicine 13(1) 19-24 Jun. 2012
  • Dialysis Disequilibrium Syndrome after Discontinuation of Hemodialysis for a Week
    Nishizaki Yuji, Komatsu Yasuhiro, Tsugawa Yusuke, Yamamoto Hiroyuki, Heath Yuki, Tamagaki Keiichi, Taki Fumika, Futatsuyama Miyuki, Ohiwa Takafumi
    General Medicine 13(1) 48-52 Jun. 2012
  • Establishment of a method to detect microalbuminuria by measuring the total urinary protein-to-creatinine ratio in diabetic patients.
    Yamamoto K, Komatsu Y, Yamamoto H, Izumo H, Sanoyama K, Monden M, Takeda K, Nakahara F, Yoshida K
    The Tohoku journal of experimental medicine 225(3) 195-202 2011 [Refereed]
    Diabetes and chronic kidney disease (CKD) which are risk facters of cardiovascular disease, are increasing global public health problems. Microalbuminuria is an early sign of progressive cardiovascular and renal disease in individuals with or without diabetes. Screening for microalbuminuria and early treatment are recommended for patients with increased cardiovascular and renal risk factors. However, the procedure used to measure urinary albumin is expensive. Alternatively, the measurement of total urinary protein is simple and inexpensive. Thus, we aimed to establish a method that could predict the presence of microalbuminuria by measuring the total protein-to-creatinine ratio. Spot urine samples were obtained from 150 patients with diabetes mellitus, and the total protein-to-creatinine ratio and the albumin-to-creatinine ratio (ACR) were measured. There was a significant positive correlation between the protein-to-creatinine ratio and the ACR (r = 0.95). The presence of albuminuria (both micro- and macroalbuminuria) could be predicted from the value of the protein-to-creatinine ratio in more than 90% of patients. A receiver-operating characteristic curve analysis revealed that the protein-to-creatinine ratio had a sensitivity and a specificity of 90.8% and 91.9%, respectively, for the detection of albuminuria and a cutoff value of 0.091 g/g creatinine. These results suggest that screening for microalbuminuria can be replaced by the detection of the protein-to-creatinine ratio, which may be cost-effective for patients with cardiovascular risks as well as for the general population.

Misc

  • 診療情報管理士の関与による大規模臨床データベースの診断情報精度向上について
    高橋 新, 福地 絵梨子, 山本 博之, 平原 憲道, 隈丸 拓, 一原 直昭, 宮田 裕章
    日本診療情報管理学会学術大会抄録集 45回 281-281 Aug. 2019
  • 医学ビックデータとICTの活用の最前線 我が国の大規模データの利活用の実際と今後の期待 外科手術データベースなどを中心に
    山本 博之
    日本透析医学会雑誌 52(Suppl.1) 337-337 May 2019
  • 透析導入の季節性は存在するか?
    川本 進也, 竹田 徹朗, 安藤 亮一, 池田 雅人, 神田 英一郎, 小岩 文彦, 小松 康宏, 常喜 信彦, 根木 茂雄, 山家 俊彦, 山本 博之, 重松 隆, 日本透析導入研究会
    日本透析医学会雑誌 52(Suppl.1) 529-529 May 2019
  • NCD24,233例を用いた、術前治療が胸腔鏡下食道切除術の短期成績に与える影響の研究結果とその課題
    吉田 直矢, 山本 博之, 宮田 裕章, 馬場 祥史, 長井 洋平, 馬場 秀夫
    日本外科学会定期学術集会抄録集 119回 SF-072 Apr. 2019
  • 安全な食道癌手術-鏡視下手術は本当に安全か?- 胸腔鏡下食道切除手術は本当に安全か? NCD症例24,233例の検討
    吉田 直矢, 馬場 祥史, 山本 博之, 馬場 秀夫
    日本臨床外科学会雑誌 79(増刊) 288-288 Oct. 2018
  • 臨床データベースの質検証作業からみる診療録の記載に関する実態と考察
    高橋 新, 福地 絵梨子, 隈丸 拓, 一原 直昭, 山本 博之, 平原 憲道, 宮田 裕章
    診療情報管理 30(2) 197-197 Aug. 2018
  • 大規模診療報酬データベースを用いた透析医学会統計調査の悉皆性の評価
    山本 博之
    日本透析医学会雑誌 51(Suppl.1) 497-497 May 2018
  • 透析導入時の尿酸値の意義
    安藤 亮一, 久山 環, 島崎 雅史, 神田 英一郎, 坂口 俊文, 池田 雅人, 稲熊 大城, 小岩 文彦, 小松 康宏, 山本 博之, 篠田 俊雄, 山家 敏彦, 根木 重雄, 重松 隆
    日本透析医学会雑誌 51(Suppl.1) 522-522 May 2018
  • 血液透析導入時の初回使用バスキュラーアクセスの現況報告 日本透析導入研究会による多施設共同検討
    根木 茂雄, 坂口 俊文, 龍田 浩一, 大矢 昌樹, 重松 隆, 安藤 亮一, 池田 雅人, 稲熊 大城, 神田 英一郎, 小岩 文彦, 小松 康宏, 篠田 俊雄, 常喜 信彦, 山家 敏彦, 山本 博之, 日本透析導入研究会
    日本透析医学会雑誌 51(Suppl.1) 619-619 May 2018
  • National Clinical Databaseにおけるデータの質検証結果報告(2014-2015年症例)
    高橋 新, 福地 絵梨子, 隈丸 拓, 一原 直昭, 山本 博之, 平原 憲道, 宮田 裕章
    日本医師事務作業補助研究会全国大会集録 7回 50-50 Nov. 2017
  • National Clinical Database(NCD)自施設データ活用におけるダウンロードデータの特徴と注意点
    高橋 新, 福地 絵梨子, 隈丸 拓, 一原 直昭, 山本 博之, 平原 憲道, 宮田 裕章
    診療情報管理 29(2) 207-207 Aug. 2017
  • 腎臓専門医長期受診と透析導入時の長期入院のリスク
    坂口 俊文, 常喜 信彦, 大矢 昌樹, 根木 重雄, 重松 隆, 安藤 亮一, 池田 雅人, 稲熊 大城, 小岩 文彦, 小松 康広, 山本 博之, 篠田 俊雄, 高山 東仁, 矢野 卓郎, 田村 渉
    日本腎臓学会誌 59(3) 323-323 Apr. 2017
  • RAS阻害薬処方CKD患者における退院後の新規高K血症発症率とリスク因子の検討
    斎藤 優樹, 山本 博之, 小松 康宏
    日本腎臓学会誌 59(3) 365-365 Apr. 2017
  • 「何のために」「いつ」するの?透析室の検査値はやわかりシート16 4)合併症に関連する検査 2)トランスフェリン飽和度(TSAT)血清フェリチン(FRN)
    山本博之
    透析ケア 23(2) 152‐154 Feb. 2017
  • Ccr・Cureaの平均および各種GFR推算式の実測GFRとの比較
    小林沙和子, 長谷川正宇, 宮内隆政, 山本博之, 藤丸拓也, ヒース雪, 瀧史香, 二ツ山みゆき, 長浜正彦, 小松康宏
    日本腎臓学会誌 58(3) 356 May 2016
  • グラフト部感染治療後に同部位からの出血性ショックをきたした1例
    松本 直人, 山本 博之, 小林 沙和子, 長谷川 正宇, 平野 寛子, 宮内 隆政, 藤丸 拓也, 瀧 史香, 二ツ山 みゆき, 長浜 正彦, 小松 康宏
    日本透析医学会雑誌 49(Suppl.1) 710-710 May 2016
  • 1週間の透析中断後に不均衡症候群を発生した一例
    西崎祐史, 金城雪, 山本博之, 瀧史香, 玉垣圭一, 二ツ山みゆき, 大岩孝誌, 小松康宏
    日本腎臓学会誌 50(6) 794 Aug. 2008
  • eGFR自動計算の導入と腎臓内科コンサルトの変化
    山本博之, 小松康宏, 玉垣圭一, 西崎祐史, 瀧史香, 二ツ山みゆき, 大岩孝誌, 武田京子, 平松園枝, 福井次矢
    日本腎臓学会誌 50(3) 376 Apr. 2008
  • 【これだけは知っておきたい分子腎臓学2007】 アクアポリンと腹膜透析
    山本 博之, 安井 正人
    腎と透析 63(4) 497-499 Oct. 2007
  • 意識障害をきたした長期維持透析患者の1例
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