HASEGAWA Daisuke

Faculty & Position:Pediatric Department  doctor
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Last Updated: Aug. 07, 2019 at 14:33

Research Activities

Research Areas

  • Clinical internal medicine / Pediatrics

Research Interests

    , Pediatrics

Published Papers

  • Clinical and molecular characteristics of MEF2D fusion-positive precursor B-cell acute lymphoblastic leukemia in childhood, including a novel translocation resulting in MEF2D-HNRNPH1 gene fusion.
    Ohki K, Kiyokawa N, Saito Y, Hirabayashi S, Nakabayashi K, Ichikawa H, Momozawa Y, Okamura K, Yoshimi A, Ogata-Kawata H, Sakamoto H, Kato M, Fukushima K, Hasegawa D, Fukushima H, Imai M, Kajiwara R, Koike T, Komori I, Matsui A, Mori M, Moriwaki K, Noguchi Y, Park MJ, Ueda T, Yamamoto S, Matsuda K, Yoshida T, Matsumoto K, Hata K, Kubo M, Matsubara Y, Takahashi H, Fukushima T, Hayashi Y, Koh K, Manabe A, Ohara A
    Haematologica Aug. 2018 [Refereed]
  • Treatment outcome of children with acute lymphoblastic leukemia: the Tokyo Children's Cancer Study Group (TCCSG) Study L04-16.
    Takahashi H, Kajiwara R, Kato M, Hasegawa D, Tomizawa D, Noguchi Y, Koike K, Toyama D, Yabe H, Kajiwara M, Fujimura J, Sotomatsu M, Ota S, Maeda M, Goto H, Kato Y, Mori T, Inukai T, Shimada H, Fukushima K, Ogawa C, Makimoto A, Fukushima T, Ohki K, Koh K, Kiyokawa N, Manabe A, Ohara A
    International journal of hematology 108(1) 98-108 Jul. 2018 [Refereed]
  • Evaluation of high-dose cytarabine in induction therapy for children with de novo acute myeloid leukemia: a study protocol of the Japan Children's Cancer Group Multi-Center Seamless Phase II-III Randomized Trial (JPLSG AML-12).
    Tomizawa D, Tanaka S, Hasegawa D, Iwamoto S, Hiramatsu H, Kiyokawa N, Miyachi H, Horibe K, Saito AM, Taga T, Adachi S
    Japanese journal of clinical oncology 48(6) 587-593 Jun. 2018 [Refereed]
  • Risk factors for psychological and psychosomatic symptoms among children with malignancies.
    Maeda K, Hasegawa D, Urayama KY, Tsujimoto S, Azami Y, Ozawa M, Manabe A
    Journal of paediatrics and child health 54(4) 411-415 Apr. 2018 [Refereed]
  • Regional evaluation of childhood acute lymphoblastic leukemia genetic susceptibility loci among Japanese.
    Urayama KY, Takagi M, Kawaguchi T, Matsuo K, Tanaka Y, Ayukawa Y, Arakawa Y, Hasegawa D, Yuza Y, Kaneko T, Noguchi Y, Taneyama Y, Ota S, Inukai T, Yanagimachi M, Keino D, Koike K, Toyama D, Nakazawa Y, Kurosawa H, Nakamura K, Moriwaki K, Goto H, Sekinaka Y, Morita D, Kato M, Takita J, Tanaka T, Inazawa J, Koh K, Ishida Y, Ohara A, Mizutani S, Matsuda F, Manabe A
    Scientific reports 8(1) 789 Jan. 2018 [Refereed]
  • Constitutional abnormalities of IDH1 combined with secondary mutations predispose a patient with Maffucci syndrome to acute lymphoblastic leukemia.
    Hirabayashi S, Seki M, Hasegawa D, Kato M, Hyakuna N, Shuo T, Kimura S, Yoshida K, Kataoka K, Fujii Y, Shiraishi Y, Chiba K, Tanaka H, Kiyokawa N, Miyano S, Ogawa S, Takita J, Manabe A
    Pediatric blood & cancer 64(12) Dec. 2017 [Refereed]
  • A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study).
    Kobayashi T, Nannya Y, Ichikawa M, Oritani K, Kanakura Y, Tomita A, Kiyoi H, Kobune M, Kato J, Kawabata H, Shindo M, Torimoto Y, Yonemura Y, Hanaoka N, Nakakuma H, Hasegawa D, Manabe A, Fujishima N, Fujii N, Tanimoto M, Morita Y, Matsuda A, Fujieda A, Katayama N, Ohashi H, Nagai H, Terada Y, Hino M, Sato K, Obara N, Chiba S, Usuki K, Ohta M, Imataki O, Uemura M, Takaku T, Komatsu N, Kitanaka A, Shimoda K, Watanabe K, Tohyama K, Takaori-Kondo A, Harigae H, Arai S, Miyazaki Y, Ozawa K, Kurokawa M, for National Research Group on Idiopathic Bone Marrow Failure Syndromes.
    American journal of hematology 92(12) 1324-1332 Dec. 2017 [Refereed]
  • Outcome of relapsed core binding factor acute myeloid leukemia in children: A result from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05R study.
    Moritake H, Tanaka S, Nakayama H, Miyamura T, Iwamoto S, Shimada A, Terui K, Saito A, Shiba N, Hayashi Y, Tomizawa D, Taga T, Goto H, Hasegawa D, Horibe K, Mizutani S, Adachi S
    Pediatric blood & cancer 64(10) Oct. 2017 [Refereed]
  • Risk Factors for Hospital-acquired Clostridium difficile Infection Among Pediatric Patients With Cancer.
    Daida A, Yoshihara H, Inai I, Hasegawa D, Ishida Y, Urayama KY, Manabe A
    Journal of pediatric hematology/oncology 39(3) e167-e172 Apr. 2017 [Refereed]
  • Infantile fibrosarcoma treated with postoperative vincristine and dactinomycin.
    Yoshihara H, Yoshimoto Y, Hosoya Y, Hasegawa D, Kawano T, Sakoda A, Okita H, Manabe A
    Pediatrics international : official journal of the Japan Pediatric Society 59(3) 371-374 Mar. 2017 [Refereed]
  • Haploidentical hematopoietic cell transplantation for disseminated Ewing sarcoma.
    Yoshihara H, Kumamoto T, Ono R, Akahane K, Nozaki T, Kobayashi S, Kikuta A, Matsumoto S, Hasegawa D, Ogawa C, Manabe A
    Pediatrics international : official journal of the Japan Pediatric Society 59(2) 223-226 Feb. 2017 [Refereed]
  • Chemotherapy for a child with relapsed acute myeloid leukemia complicated with persistent hepatitis C virus infection.
    Kimura S, Hirabayashi S, Hasegawa D, Sumiya W, Seya M, Matsui T, Yoshimoto Y, Hosoya Y, Mori N, Matsui A, Manabe A
    [Rinsho ketsueki] The Japanese journal of clinical hematology 58(6) 619-623 2017 [Refereed]
  • Ewing sarcoma/primitive neuroectodermal tumor of the kidney treated with chemotherapy including ifosfamide.
    Yoshihara H, Kamiya T, Hosoya Y, Hasegawa D, Ogawa C, Asanuma H, Mizuno R, Hosoya R, Manabe A
    Pediatrics international : official journal of the Japan Pediatric Society 58(8) 766-769 Aug. 2016 [Refereed]
    :Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) of the kidney is extremely rare, and is usually diagnosed after nephrectomy without neoadjuvant chemotherapy. Although ifosfamide and etoposide improve survival to a great extent in ES/PNET, the use of nephrotoxic agent, particularly ifosfamide, is a concern after nephrectomy. We describe the case of a 14-year-old female patient with abdomin
  • Scurvy: From a Selective Diet in Children with Developmental Delay.
    Seya M, Handa A, Hasegawa D, Matsui T, Nozaki T
    The Journal of pediatrics 177 331 Jul. 2016 [Refereed]
  • Severe 6-mercaptopurine-induced hematotoxicity in childhood an ALL patient with homozygous NUDT15 missence variants.
    Kimura S, Hasegawa D, Yoshimoto Y, Hirabayashi S, Hosoya Y, Yoshihara H, Kumamoto T, Tanaka Y, Manabe A
    [Rinsho ketsueki] The Japanese journal of clinical hematology 57(6) 748-753 Jun. 2016 [Refereed]
    :Thiopurine S-methyltransferase (TPMT) and nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) variants are considered to be genes responsible for severe myelotoxicity induced by 6-mercaptopurine (6MP). We report a 4-year-old girl with acute lymphoblastic leukemia, who developed the complication of severe 6MP-induced myelotoxicity due to homozygous NUDT15 variant alleles. In early consol
  • A Cytokine-Based Diagnostic Program in Pediatric Aplastic Anemia and Hypocellular Refractory Cytopenia of Childhood.
    Elmahdi S, Hama A, Manabe A, Hasegawa D, Muramatsu H, Narita A, Nishio N, Ismael O, Kawashima N, Okuno Y, Xu Y, Wang X, Takahashi Y, Ito M, Kojima S
    Pediatric blood & cancer 63(4) 652-658 Apr. 2016 [Refereed]
    BACKGROUND:Distinguishing hypocellular refractory cytopenia of childhood (RCC) from aplastic anemia (AA) is challenging. Thus far, no studies have compared the cytokine profiles in patients with AA to those with hypocellular RCC. In the present study, we addressed whether thrombopoietin (TPO) and interleukin 17 (IL-17) plasma levels are useful for differentiating between the two diseases.;METHODS:
  • The current perspective of low-grade myelodysplastic syndrome in children.
    Hasegawa D
    International journal of hematology 103(4) 360-364 Apr. 2016 [Refereed]
    :Myelodysplastic syndrome (MDS) without increased blasts, i.e., low-grade MDS, is the most common subtype of pediatric MDS and has characteristics different from adult form of the disease. Although histological findings of bone marrow (BM) biopsies suggest that low-grade MDS is a morphologically distinctive entity, a subset of pediatric low-grade MDS may clinically overlap with aplastic anemia (AA
  • Cervical ultrasound and computed tomography of Kawasaki disease: Comparison with lymphadenitis.
    Nozaki T, Morita Y, Hasegawa D, Makidono A, Yoshimoto Y, Starkey J, Kusakawa I, Manabe A, Saida Y
    Pediatrics international : official journal of the Japan Pediatric Society 58(11) 1146-1152 Apr. 2016 [Refereed]
    BACKGROUND:Differentiating Kawasaki disease (KD) from cervical lymphadenitis (CL) is clinically difficult but essential given that treatment and outcome differ significantly. Research on differentiation between KD and CL using ultrasound (US) and computed tomography (CT) is limited. The purpose of this study was to identify cervical US and CT findings that may differentiate KD from CL.;METHODS:We
  • Successful unrelated cord blood transplantation in a child with very severe aplastic anemia
    Kimura Shunsuke;Hasegawa Daisuke;Matsui Toshihiro;Daida Atsuro;Ishida Hisashi;Yoshimoto Yuri;Hirabayashi Shinsuke;Hosoya Yosuke;Yoshihara Hiroki;Kumamoto Tadashi;Mori Shinichiro;Manabe Atsushi
    The Japanese Journal of Pediatric Hematology / Oncology 53(1) 21-25 2016
    Unrelated cord blood transplantation (UCBT) and mismatched related donor stem cell transplantation (MMRD-SCT) have been considered as alternative therapeutic options for patients with very severe aplastic anemia (VSAA) and severe infection when an HLA-matched donor is not available. However, a high rate of graft failure and severe graft-versus-host disease (GVHD) are the major problems in SCT from
  • Respiratory syncytial virus infection in infants with acute leukemia: a retrospective survey of the Japanese Pediatric Leukemia/Lymphoma Study Group.
    Hatanaka M, Miyamura T, Koh K, Taga T, Tawa A, Hasegawa D, Kajihara R, Adachi S, Ishii E, Tomizawa D
    International journal of hematology 102(6) 697-701 Dec. 2015 [Refereed]
    :Respiratory syncytial virus (RSV) can cause life-threatening complications of lower respiratory tract infection (LRTI) in young children with malignancies, but reports remain limited. We performed a retrospective nationwide survey to clarify the current status of RSV disease among infants with hematological malignancies. Clinical course, treatment, and outcome of patients with hematological malig
  • Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia.
    Tanaka Y, Kato M, Hasegawa D, Urayama KY, Nakadate H, Kondoh K, Nakamura K, Koh K, Komiyama T, Manabe A
    British journal of haematology 171(1) 109-115 Oct. 2015 [Refereed]
    :Genotyping of TPMT prior to 6-mercaptopurine (6-MP) administration in acute lymphoblastic leukaemia (ALL) patients has been integrated into clinical practice in some populations of European ancestry. However, the comparable rates of 6-MP myelotoxicity, but rarity of TPMT variants, in Asians suggest that major determinants have yet to be discovered in this population. We genotyped 92 Japanese paed
  • Acute megakaryoblastic leukemia with acquired trisomy 21 and GATA1 mutations in phenotypically normal children.
    Ono R, Hasegawa D, Hirabayashi S, Kamiya T, Yoshida K, Yonekawa S, Ogawa C, Hosoya R, Toki T, Terui K, Ito E, Manabe A
    European journal of pediatrics 174(4) 525-531 Apr. 2015 [Refereed]
  • Acute megakaryoblastic leukemia with acquired trisomy 21 and GATA1 mutations in phenotypically normal children.
    Ono Rintaro;Hasegawa Daisuke;Hirabayashi Shinsuke;Kamiya Takahiro;Yoshida Kenichi;Yonekawa Satoko;Ogawa Chitose;Hosoya Ryota;Toki Tsutomu;Terui Kiminori;Ito Etsuro;Manabe Atsushi
    Acute megakaryoblastic leukemia with acquired trisomy 21 and GATA1 mutations in phenotypically normal children. 174(4) 2015
    UNLABELLED:GATA1 mutations are found almost exclusively in children with myeloid proliferations related to Down syndrome (DS). Here, we report two phenotypically and cytogenetically normal children with acute megakaryoblastic leukemia (AMKL) whose blasts had both acquired trisomy 21 and GATA1 mutation. Patient 1 was diagnosed with transient abnormal myelopoiesis in the neonatal period. Following s
  • Clinical characteristics and treatment outcome in 65 cases with refractory cytopenia of childhood defined according to the WHO 2008 classification.
    Hasegawa D, Chen X, Hirabayashi S, Ishida Y, Watanabe S, Zaike Y, Tsuchida M, Masunaga A, Yoshimi A, Hama A, Kojima S, Ito M, Nakahata T, Manabe A
    British journal of haematology 166(5) 758-766 Sep. 2014 [Refereed]
  • Treatment outcomes of adolescent acute lymphoblastic leukemia treated on Tokyo Children's Cancer Study Group (TCCSG) clinical trials.
    Kato M, Manabe A, Koh K, Inukai T, Kiyokawa N, Fukushima T, Goto H, Hasegawa D, Ogawa C, Koike K, Ota S, Noguchi Y, Kikuchi A, Tsuchida M, Ohara A
    International journal of hematology 100(2) 180-187 Aug. 2014 [Refereed]
  • No impact of high-dose cytarabine and asparaginase as early intensification with intermediate-risk paediatric acute lymphoblastic leukaemia: results of randomized trial TCCSG study L99-15.
    Kato M, Koh K, Manabe A, Saito T, Hasegawa D, Isoyama K, Kinoshita A, Maeda M, Okimoto Y, Kajiwara M, Kaneko T, Sugita K, Kikuchi A, Tsuchida M, Ohara A
    British journal of haematology 164(3) 376-383 Feb. 2014 [Refereed]
  • Significance of CD66c expression in childhood acute lymphoblastic leukemia.
    Kiyokawa N, Iijima K, Tomita O, Miharu M, Hasegawa D, Kobayashi K, Okita H, Kajiwara M, Shimada H, Inukai T, Makimoto A, Fukushima T, Nanmoku T, Koh K, Manabe A, Kikuchi A, Sugita K, Fujimoto J, Hayashi Y, Ohara A
    Leukemia research 38(1) 42-48 Jan. 2014 [Refereed]
  • Significance of CD66c expression in childhood acute lymphoblastic leukemia.
    Kiyokawa Nobutaka;Iijima Kazutoshi;Tomita Osamu;Miharu Masashi;Hasegawa Daisuke;Kobayashi Kenichiro;Okita Hajime;Kajiwara Michiko;Shimada Hiroyuki;Inukai Takeshi;Makimoto Atsushi;Fukushima Takashi;Nanmoku Toru;Koh Katsuyoshi;Manabe Atsushi;Kikuchi Akira;Sugita Kanji;Fujimoto Junichiro;Hayashi Yasuhide;Ohara Akira
    Significance of CD66c expression in childhood acute lymphoblastic leukemia. 38(1) 2014
    :Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p<0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4),
  • Clinical characteristics and treatment outcome in 65 cases with refractory cytopenia of childhood defined according to the WHO 2008 classification.
    Hasegawa Daisuke;Chen Xiaojuan;Hirabayashi Shinsuke;Ishida Yasushi;Watanabe Shizuka;Zaike Yuji;Tsuchida Masahiro;Masunaga Atsuko;Yoshimi Ayami;Hama Asahito;Kojima Seiji;Ito Masafumi;Nakahata Tatsutoshi;Manabe Atsushi
    Clinical characteristics and treatment outcome in 65 cases with refractory cytopenia of childhood defined according to the WHO 2008 classification. 166(5) 2014
    :This study analysed 65 children who were prospectively registered between 1999 and 2008 and fulfilled the World Health Organization 2008 criteria of refractory cytopenia of childhood (RCC). First-line therapy was determined by the treating physicians: 25 patients received immunosuppressive therapy (IST), 12 patients received haematopoietic stem cell transplantation (HSCT) and one patient received
  • The landscape of somatic mutations in Down syndrome-related myeloid disorders.
    Yoshida K, Toki T, Okuno Y, Kanezaki R, Shiraishi Y, Sato-Otsubo A, Sanada M, Park MJ, Terui K, Suzuki H, Kon A, Nagata Y, Sato Y, Wang R, Shiba N, Chiba K, Tanaka H, Hama A, Muramatsu H, Hasegawa D, Nakamura K, Kanegane H, Tsukamoto K, Adachi S, Kawakami K, Kato K, Nishimura R, Izraeli S, Hayashi Y, Miyano S, Kojima S, Ito E, Ogawa S
    Nature genetics 45(11) 1293-1299 Nov. 2013 [Refereed]
  • Aggressive transformation of juvenile myelomonocytic leukemia associated with duplication of oncogenic KRAS due to acquired uniparental disomy.
    Kato M, Yasui N, Seki M, Kishimoto H, Sato-Otsubo A, Hasegawa D, Kiyokawa N, Hanada R, Ogawa S, Manabe A, Takita J, Koh K
    The Journal of pediatrics 162(6) 1285-8, 1288.e1 Jun. 2013 [Refereed]
  • [Childhood acute lymphoblastic leukemia (ALL)].
    Manabe A, Hasegawa D
    [Rinsho ketsueki] The Japanese journal of clinical hematology 54(1) 100-108 Jan. 2013 [Refereed]
  • Outcome of children with refractory anaemia with excess of blast (RAEB) and RAEB in transformation (RAEB-T) in the Japanese MDS99 study.
    Kikuchi A, Hasegawa D, Ohtsuka Y, Hamamoto K, Kojima S, Okamura J, Nakahata T, Manabe A, Japanese Paediatric Myelodysplastic Syndrome (MDS) Study Group
    British journal of haematology 158(5) 657-661 Sep. 2012 [Refereed]
  • [Myelodysplastic syndrome in childhood and juvenile myelomonocytic leukemia].
    Hasegawa D, Manabe A
    Nihon rinsho. Japanese journal of clinical medicine 70 Suppl 2 681-686 Apr. 2012 [Refereed]
  • CBL mutation in chronic myelomonocytic leukemia secondary to familial platelet disorder with propensity to develop acute myeloid leukemia (FPD/AML).
    Shiba N, Hasegawa D, Park MJ, Murata C, Sato-Otsubo A, Ogawa C, Manabe A, Arakawa H, Ogawa S, Hayashi Y
    Blood 119(11) 2612-2614 Mar. 2012 [Refereed]
  • The utility of performing the initial lumbar puncture on day 8 in remission induction therapy for childhood acute lymphoblastic leukemia: TCCSG L99-15 study.
    Hasegawa D, Manabe A, Ohara A, Kikuchi A, Koh K, Kiyokawa N, Fukushima T, Ishida Y, Saito T, Hanada R, Tsuchida M, Tokyo Children's Cancer Study Group
    Pediatric blood & cancer 58(1) 23-30 Jan. 2012 [Refereed]
  • Intellectual development after treatment in children with acute leukemia and brain tumor.
    Watanabe S, Azami Y, Ozawa M, Kamiya T, Hasegawa D, Ogawa C, Ishida Y, Hosoya R, Kizu J, Manabe A
    Pediatrics international : official journal of the Japan Pediatric Society 53(5) 694-700 Oct. 2011 [Refereed]
  • Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia.
    Kanezaki R, Toki T, Terui K, Xu G, Wang R, Shimada A, Hama A, Kanegane H, Kawakami K, Endo M, Hasegawa D, Kogawa K, Adachi S, Ikeda Y, Iwamoto S, Taga T, Kosaka Y, Kojima S, Hayashi Y, Ito E
    Blood 116(22) 4631-4638 Nov. 2010 [Refereed]
  • Bullous exudative retinal detachment due to infiltration of leukemic cells in a child with acute lymphoblastic leukemia.
    Yoshida K, Hasegawa D, Takusagawa A, Kato I, Ogawa C, Echizen N, Ohkoshi K, Yamaguchi T, Hosoya R, Manabe A
    International journal of hematology 92(3) 535-537 Oct. 2010 [Refereed]
  • Treatment of children with refractory anemia: the Japanese Childhood MDS Study Group trial (MDS99).
    Hasegawa D, Manabe A, Yagasaki H, Ohtsuka Y, Inoue M, Kikuchi A, Ohara A, Tsuchida M, Kojima S, Nakahata T, Japanese Childhood MDS Study Group
    Pediatric blood & cancer 53(6) 1011-1015 Dec. 2009 [Refereed]
  • Detection of submicroscopic disease in the bone marrow and unaffected testis of a child with T-cell acute lymphoblastic leukemia who experienced "isolated" testicular relapse.
    Arima K, Hasegawa D, Ogawa C, Kato I, Imamura T, Takusagawa A, Takahashi H, Kitagawa Y, Hori T, Tsurusawa M, Manabe A, Hosoya R
    International journal of hematology 90(3) 370-373 Oct. 2009 [Refereed]
  • The ex vivo production of ammonia predicts L-asparaginase biological activity in children with acute lymphoblastic leukemia.
    Watanabe S, Miyake K, Ogawa C, Matsumoto H, Yoshida K, Hirabayashi S, Hasegawa D, Inoue T, Kizu J, Machida R, Ohara A, Hosoya R, Manabe A
    International journal of hematology 90(3) 347-352 Oct. 2009 [Refereed]
  • Significance of the complete clearance of peripheral blasts after 7 days of prednisolone treatment in children with acute lymphoblastic leukemia: the Tokyo Children's Cancer Study Group Study L99-15.
    Manabe A, Ohara A, Hasegawa D, Koh K, Saito T, Kiyokawa N, Kikuchi A, Takahashi H, Ikuta K, Hayashi Y, Hanada R, Tsuchida M, Tokyo Children's Cancer Study Group
    Haematologica 93(8) 1155-1160 Aug. 2008 [Refereed]
  • Clinical application of rapid assay of serum interleukin-6 in Kawasaki disease.
    Suganami Y, Kawashima H, Hasegawa D, Sato S, Hoshika A
    Pediatrics international : official journal of the Japan Pediatric Society 50(2) 264-266 Apr. 2008 [Refereed]
  • The effect of donor leukocyte infusion on refractory pure red blood cell aplasia after allogeneic stem cell transplantation in a patient with myelodysplastic syndrome developing from Kostmann syndrome.
    Ebihara Y, Manabe A, Tsuruta T, Ishikawa K, Hasegawa D, Ohtsuka Y, Kawasaki H, Ogami K, Wada Y, Kanda T, Tsuji K
    International journal of hematology 86(5) 446-450 Dec. 2007 [Refereed]
  • Hazards of early BCG vaccination: BCGitis in a patient with chronic granulomatous disease.
    Kawashima H, Hasegawa D, Nakamura M, Mochizuki S, Kashiwagi Y, Nishimata S, Sato S, Sasamoto M, Takekuma K, Hoshika A, Nunoi H
    Pediatrics international : official journal of the Japan Pediatric Society 49(3) 418-419 Jun. 2007 [Refereed]
  • RAS-blocking bisphosphonate zoledronic acid inhibits the abnormal proliferation and differentiation of juvenile myelomonocytic leukemia cells in vitro.
    Ohtsuka Y, Manabe A, Kawasaki H, Hasegawa D, Zaike Y, Watanabe S, Tanizawa T, Nakahata T, Tsuji K
    Blood 106(9) 3134-3141 Nov. 2005 [Refereed]
  • Virological and immunological characteristics of a 19-year-old Japanese female with fatal outcome with Epstein-Barr virus-associated hemophagocytic syndrome.
    Sato S, Kawashima H, Oshiro H, Hasegawa D, Kashiwagi Y, Takekuma K, Hoshika A
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 31(3) 235-238 Nov. 2004 [Refereed]
  • Rapid diagnosis of bacterial meningitis by using multiplex PCR and real time PCR.
    Uzuka R, Kawashima H, Hasegawa D, Ioi H, Amaha M, Kashiwagi Y, Takekuma K, Hoshika A, Chiba K
    Pediatrics international : official journal of the Japan Pediatric Society 46(5) 551-554 Oct. 2004 [Refereed]

Conference Activities & Talks

  • 非血縁同種骨髄移植後に重症腎TMAを発症した骨髄異形成症候群の8歳女児例
    宮本智史, 宮本智史, 木村俊介, 石田悠志, 代田惇朗, 松井俊大, 吉本優里, 平林真介, 細谷要介, 藤丸拓也, 長谷川大輔, 熊本忠史, 森慎一郎, 鈴木高祐, 真部淳
    日本造血細胞移植学会総会プログラム・抄録集 Feb. 2016
  • 水痘感染の既往のない非血縁者間臍帯血移植後男児に生じた帯状疱疹
    木村俊介, 長谷川大輔, 代田惇朗, 松井俊大, 吉本優里, 平林真介, 細谷要介, 熊本忠志, 真部淳
    日本小児科学会雑誌 Feb. 2016
  • 自閉症スペクトラム障害のフォロー中に発作時脳波での鑑別を要した前頭葉てんかん
    角谷和歌子, 代田惇朗, 松井俊大, 田中育子, 横山美奈, 長谷川大輔, 小澤美和, 荻原正明, 草川功, 真部淳
    日本小児科学会雑誌 Feb. 2016
  • 再生不良性貧血・骨髄増殖性疾患 治療関連骨髄異形成症候群44例の臨床像(Aplastic anemia and myeloproliferative disorder Clinical characteristics of 44 cases with therapy-related myelodysplastic syndrome in childhood)
    長谷川 大輔, 濱 麻人, 野沢 和江, 平林 真介, 渡邉 健一郎, 土田 昌宏, 伊藤 雅文, 小島 勢二, 中畑 龍俊, 真部 淳
    日本小児血液・がん学会雑誌 Oct. 2015
  • わが国の小児がん医療提供体制について考える 小児がんに対するトータルケアと医療提供体制
    長谷川 大輔, 小澤 美和, 真部 淳, 細谷 亮太
    日本小児血液・がん学会雑誌 Oct. 2015
  • 蛋白漏出性胃腸症で発症したHenoch-Schoenlein紫斑病の一例
    孫 楽, 吉本 優里, 小野 林太郎, 長谷川 大輔, 小澤 美和, 真部 淳, 草川 功
    日本小児科学会雑誌 Feb. 2014
  • 小児不応性血球減少症の臨床像の検討 日本小児血液学会前方視的登録例より
    長谷川 大輔, 在家 裕司, 土田 昌宏, 増永 敦子, 吉見 礼美, 濱 麻人, 小島 勢二, 伊藤 雅文, 中畑 龍俊, 真部 淳, 日本小児血液・がん学会MDS委員会
    日本小児科学会雑誌 Feb. 2013
  • 肝脾型γδT細胞性リンパ腫/白血病と骨髄異形成症候群を合併した3歳女児例
    寺尾 陽子, 秋山 政晴, 山岡 正慶, 横井 健太郎, 井田 博幸, 長谷川 大輔, 熊本 忠史, 小川 千登世, 真部 淳
    臨床血液 Dec. 2012
  • 致死的な血球貪食症候群を来したUPD-14の1例
    米川 聡子, 居石 崇志, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 草川 功, 真部 淳, 野崎 太希, 川野 孝文, 細谷 亮太
    日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号 Nov. 2012
  • 母の作ったファンタジーの中で生きていこうとしている弟の課題
    植松 温子, 関冨 晶子, 小澤 美和, 長谷川 大輔, 馬場 徳朗, 細谷 亮太
    日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号 Nov. 2012
  • 当院における小児がんの患児への告知に関する過去20年の検討
    吉本 優里, 上野 浩生, 吉原 宏樹, 細谷 要介, 長谷川 大輔, 小澤 美和, 石田 也寸志, 真部 淳, 細谷 亮太
    日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号 Nov. 2012

Misc

  • Pearson症候群 日本小児血液がん学会中央診断登録例より
    長谷川 大輔
    日本小児血液・がん学会雑誌 52(5) 477-477 Feb. 2016
  • 若年性骨髄単球性白血病と鑑別が必要な疾患
    長谷川 大輔
    日本小児血液・がん学会雑誌 52(3) 304-310 Oct. 2015
    若年性骨髄単球性白血病(JMML)は乳幼児に好発する多能性造血幹細胞のクローン性異常で、約90%の症例でRAS/MAPK経路に関与する遺伝子の変異が検出される。これら変異の存在に加え、脾腫、白血球増加および単球増加などの所見に基づき診断するが、変異陰性例では時に診断に苦慮する。乳児期に生じたサイトメガロウイルス感染症では肝脾腫や単球増加などJMML様の臨床像を呈することがあるが自然軽快する。一方、ウイルス感染を偶然に併発しているJMMLを無治療で経過観察すると病勢進行を来しうる。Wiskott-Aldrich症候群(WAS)も血小板減少に加えて単球増加を認めることがある。この場合、WASに特徴的な小型血小板ではなく巨大血小板を認めることが多い。他に乳児悪性型大理石病や白血球接着不全症なども時にJMMLとの鑑別が必要となる。最近、RAS体細胞変異によって自己免疫性リンパ増殖症候群(ALPS)ともJMMLとも鑑別困難な病態を来すことが報告され、RALD(RAS-associated ALPS-like disease)と称される。以前からJMMLの一部で高IgG血症や自己抗体の出現をみることが知られていたが、病勢の緩徐なRAS変異陽性JMMLの一部はRALDの可能性がある一方、致死的経過を辿ることもあり、予後や適切な管理法について今後の症例の蓄積が必要である。(著者抄録)
  • 【小児血液疾患-よくわかる最新知見-】 造血器悪性疾患 骨髄異形成症候群
    長谷川 大輔
    小児科 55(11) 1737-1744 Oct. 2014
  • JMMLと鑑別が必要な疾患
    長谷川 大輔
    日本小児血液・がん学会雑誌 51(4) 185-185 Oct. 2014
  • Advanced MDSの治療を考える Introduction
    長谷川 大輔
    日本小児血液・がん学会雑誌 51(3) 300-300 Sep. 2014
  • RAS変異陽性若年性骨髄単球性白血病(JMML)を考える Introduction
    長谷川 大輔
    日本小児血液・がん学会雑誌 50(3) 494-494 Oct. 2013
  • 【臨床血液学 今後の展望(2013年版)-リンパ系疾患-】 小児急性リンパ性白血病
    真部 淳, 長谷川 大輔
    臨床血液 54(1) 100-108 Jan. 2013
  • 【MDS(骨髄異形成症候群)】 小児のMDS
    長谷川 大輔, 真部 淳
    臨床検査 56(12) 1377-1384 Nov. 2012
  • 【小児疾患の診断治療基準(第4版)】 (第2部)疾患 血液・造血器疾患 骨髄異形成症候群
    長谷川 大輔
    小児内科 44(増刊) 576-577 Nov. 2012
  • 【MDSをめぐる最近の進歩-治癒を目指して】 小児MDSの特徴と病態解析研究の進歩
    長谷川 大輔, 濱 麻人, 滝 智彦
    血液内科 65(3) 334-342 Sep. 2012
  • 小児がん経験者の晩期合併症の予測は可能か 聖路加国際病院小児科の経験
    石田 也寸志, 渡辺 静, 小澤 美和, 米川 聡子, 小川 千登世, 長谷川 大輔, 細谷 要介, 吉原 宏樹, 真部 淳, 森本 克, 西村 昴三, 細谷 亮太
    日本小児血液・がん学会雑誌 49(1-2) 31-39 May 2012
    JPLSG長期フォローアップ(FU)委員会の5段階のFUレベルが、晩期合併症発症の予想に役立つかどうか検証した。【対象と方法】研究デザインはレトロスペクティブコホート研究で、対象は1972年から2011年に当院小児科で診療した小児がん症例で治療を終了しているものである。治療終了時FUレベルと最終観察日の晩期合併症について単変量とロジステック解析を行いオッズ比(OR)を求めた。【結果】2011年3月31日の時点で生存していた388例で、FUレベル判定不能88例を除き、残り300例を解析した。血液がんではレベル3=41%、4=37%、脳腫瘍はレベル4=100%、固形腫瘍はレベル2=25%、レベル3=44%、LCHはレベル1=62%、骨軟部腫瘍はレベル3=36%、4=25%、5=40%であった。晩期合併症は、レベル1:0%、レベル2:15%、レベル3:37%、レベル4:72%、レベル5:100%で、ロジスティク解析では、脳腫瘍(OR:65.4)、固形腫瘍(OR:3.45)、骨軟部腫瘍(OR:10.4)、最終観察年齢26歳以上(OR:6.75)、CPM>5g/m2(OR:5.64)、同種造血細胞移植(OR:10.9)が晩期合併症の独立したリスク因子であった。【結語】治療終了時の5段階のFUレベル評価は晩期合併症の予測に有用であり、この分類を活用することによりリスクに基づいたFU計画の立案が可能である。(著者抄録)


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