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佐々木 清寿 ササキ セイジュ

所属・職名:予防医療センター  医師
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更新日: 20/09/03 05:04

研究者基本情報

学位

  • 医学博士

学歴

  • - 1985年03月岩手医科大学 医学部

所属学協会

    日本がん検診・診断学会 , 日本総合健診医学会 , 日本超音波医学会 , 日本肝臓学会 , 日本消化器がん検診学会 , 日本消化器内視鏡学会 , 日本消化器病学会 , 日本内科学会

委員歴

  • - 現在厚生労働省「検診ガイドライン作成と科学的根拠に基づく検診推進のための研究」(R1) 委員
  • - 現在日本総合健診医学会 審議員
  • - 現在日本がん検診・診断学会 評議員
  • - 現在日本消化器内視鏡学会 関東支部評議員
  • - 2019年厚生労働省「子宮頸がん検診エビデンズレポート」(R1) 委員
  • - 2018年「有効性評価に基づくがん検診ガイドライン」のためのエビデンスレポート作成方法 文献レビュー委員会委員
  • - 2011年厚生労働省「乳がん検診ガイドライン」(H23) 研究員
  • - 2010年厚生労働省「肝炎ウイルス・肝がんエビデンスレポート」(H22) 研究員
  • - 2004年厚生労働省「胃がん検診ガイドライン」(H16) 研究員
  • 日本消化器がん検診学会 代議員

研究活動情報

研究分野

  • ライフサイエンス / 内科学一般

論文

  • Frequency of unsatisfactory cervical cytology smears in cancer screening of Japanese women: A systematic review and meta-analysis
    Satoyo Hosono, Teruhiko Terasawa, Takafumi Katayama, Seiju Sasaki, Keika Hoshi, Chisato Hamashima
    Cancer Science 109(4) 934-943 2018年04月 [査読有り]
    The Bethesda system (TBS) has been used for cervical cytological diagnosis in Japan since 2008. Evaluation of specimen adequacy is the most important aspect of quality assurance and for precise diagnosis in TBS. A systematic review and meta-analysis were carried out to assess the unsatisfactory specimen rate in the primary cervical cancer screening setting in Japan. Ovid Medline and Ichushi-Web databases were searched from inception through to May 2017. Prospective and retrospective studies that reported the proportion of unsatisfactory specimens in healthy asymptomatic Japanese women in a cervical cancer screening program were eligible for inclusion 17 studies were included in the meta-analysis. The random-effects model meta-analysis calculated summary estimates of the unsatisfactory rate of 0.60% (95% confidence interval [CI], 0.18-1.96% I2 = 99%) for conventional cytology and 0.04% (95% CI, 0.00-0.35% I2 = 99%) for liquid-based cytology (LBC). However, comparative results between conventional and liquid-based cytology, based on four direct and nine comparative studies, showed no significant difference (summary odds ratio = 3.5 × 10−2 favoring LBC [95% CI, 6.9 × 10−4-1.7] I2 = 98%). In the subgroup analyses and meta-regressions, use of non-cotton devices for conventional cytology and use of a particular platform for LBC were associated with lower unsatisfactory rates. Meta-regression also suggested chronological improvement in unsatisfactory rates for both tests. In Japanese cervical cancer screening programs, conventional cytology remains prevalent. Future research needs to focus on evaluating the impact of screening programs using LBC by comparing the accuracy, performance, and cost-effectiveness with conventional cytology in the Japanese population.
  • The Japanese Guidelines for Breast Cancer Screening.
    Chisato Hamashima, Chisato Hamashima C, Masakazu Hattori, Satoshi Honjo, Yoshio Kasahara, Takafumi Katayama, Masahiro Nakai, Tomio Nakayama, Takako Morita, Koji Ohta, Koji Ohnuki, Motoyasu Sagawa, Hiroshi Saito, Seiju Sasaki, Tomoyuki Shimada, Tomotaka Sobue, Akihiko Suto
    Japanese journal of clinical oncology 46(5) 482-92 2016年05月 [査読有り]
    OBJECTIVE: The incidence of breast cancer has progressively increased, making it the leading cause of cancer deaths in Japan. Breast cancer accounts for 20.4% of all new cancers with a reported age-standardized rate of 63.6 per 100 000 women. METHODS: The Japanese guidelines for breast cancer screening were developed based on a previously established method. The efficacies of mammography with and without clinical breast examination, clinical breast examination and ultrasonography with and without mammography were evaluated. Based on the balance of the benefits and harms, recommendations for population-based and opportunistic screenings were formulated. RESULTS: Five randomized controlled trials of mammographic screening without clinical breast examination were identified for mortality reduction from breast cancer. The overall relative risk for women aged 40-74 years was 0.75 (95% CI: 0.67-0.83). Three randomized controlled trials of mammographic screening with clinical breast examination served as eligible evidence for mortality reduction from breast cancer. The overall relative risk for women aged 40-64 years was 0.87 (95% confidence interval: 0.77-0.98). The major harms of mammographic screening were radiation exposure, false-positive cases and overdiagnosis. Although two case-control studies evaluating mortality reduction from breast cancer were found for clinical breast examination, there was no study assessing the effectiveness of ultrasonography for breast cancer screening. CONCLUSIONS: Mammographic screening without clinical breast examination for women aged 40-74 years and with clinical breast examination for women aged 40-64 years is recommended for population-based and opportunistic screenings. Clinical breast examination and ultrasonography are not recommended for population-based screening because of insufficient evidence regarding their effectiveness.
  • Nonalcoholic fatty liver disease is a marker for atherogenic dyslipidemia
    Kimura Takeshi, Yoshida Chihoko, Sasaki Seiju, Takahashi Osamu, Ohde Sachiko, Hiramatsu Sonoe
    GASTROENTEROLOGY 134(4) A18 2008年04月 [査読有り]

競争的資金

  • 「健診受診者を対象とした、包括的リスク管理チャートに基づく記載疫学」
    日本総合健診医学会:総合健診医学会学術奨励助成
    研究期間:2016年01月 - 2017年  

社会貢献活動情報

社会貢献活動